Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

Table 4

Effect of LTG on anxiety behaviour in male and female offspring.

Group	Treatment	Sex	Number of entries		Time spent (sec)
			Open	Closed	Open	Closed
I	Control	Male	2.50±0.50	10.25±1.18	112.25±12.94	187.75±12.94
		Female	3.00±1.34	11.00±0.84	122.40±9.92	177.60±9.92
II	LTG; (11.5 mg/kg, p.o)	Male	2.08±0.94	7.03±1.25	133.72±28.13	166.28±28.13
		Female	4.67±1.00	9.67±1.16	97.92±16.89	202.08±16.89
III	LTG; (23 mg/kg, p.o)	Male	2.83±0.48	8.00±0.73	147.33±10.97	152.67±10.97
		Female	10.50±2.50^∗	3.50±0.50^∗∗	262.50±4.50^∗∗	37.50±4.50^∗∗

𝑛=8/group (4/sex). Values are expressed in mean ± SEM. Significance with Tukey’s test following one way ANOVA is indicated as ^∗𝑃≤0.05 and ^∗∗𝑃≤0.01 versus control group.