Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

Table 6

Effect of LTG on learning and memory function in male and female offspring.

Group	Treatment	Sex	Lag period	Number of reference; memory errors	Number of working; memory errors	Number of correct; entries	Total time taken to; munch the food
I	Control	Male	1.00±0.00	1.83±0.80	0.42±0.12	2.25±0.74	82.50±19.04
		Female	0.33±0.20	0.73±0.37	0.20±0.13	2.53±0.51	88.93±15.81
II	LTG (11.5 mg/kg, p.o)	Male	1.06±0.41	2.67±0.44	0.28±0.08	1.22±0.43	137.11±15.54
		Female	0.32±0.10	2.67±0.74	1.17±0.50	1.33±0.89	113.17±15.00
III	LTG (23 mg/kg, p.o)	Male	1.25±0.33	3.00±0.74	0.71±0.17	1.25±0.53	141.25±15.68
		Female	0.47±0.22	1.46±0.72	0.75±0.43	2.33±0.69	63.71±19.24

𝑛=8/group (4/sex). Values are expressed in mean ± SEM.