Coexisting Iron Deficiency Anemia and Beta Thalassemia Trait: Effect of Iron Therapy on Red Cell Parameters and Hemoglobin Subtypes

Table 1

Pre- and posttherapy hematological and biochemical parameters.

Parameter	Pretherapy	Posttherapy	𝑃 value
Hemoglobin (g/dL)	9.8±1.1	10.8±1.11	<0.001
RBC count (million/mm^3)	4.9±0.85	5.1±0.76	0.35
Mean corpuscular volume, MCV (fL)	64.0±6.44	67.9±4.84	0.01
Mean corpuscular hemoglobin, MCH (pg)	20.0±3.0	21.5±3.01	0.04
Mean corpuscular hemoglobin concentration	30.2±2.35	31.4±2.11	0.04
Red cell distribution width, RDW-CV (%)	18.6±2.13	16.08±1.53	<0.001
Serum iron (𝜇g/dL)	47.1±8.17	70.3±8.15	<0.001
TIBC (𝜇g/dL)	502±34.17	383.2±22.18	<0.001
Ferritin (ng/mL)*	6.75	25.9	<0.001
	(QD 1.175)	(QD 10.96)
HbF (%)	0.9±0.8	0.9±0.84	0.98
HbA2 (%)	5.4±0.86	5.8±0.87	0.04

∗Ferritin in median values; QD: quartile deviation.