p16 Expression Is Lost in Severely Atypical Cellular Blue Nevi and Melanoma Compared to Conventional, Mildly, and Moderately Atypical Cellular Blue Nevi
Figure 1
p16 staining intensity (a) and percentage of melanocytes stained with p16 (b) and Ki-67 (c) in conventional benign and atypical nevi, CBN, melanoma, and malignant CBN. (a, b) p16 staining was higher in all CBN when compared to melanoma ( and ) and malignant CBN ( and ). Upon subclassifying the CBN based on degree of atypia, a significant increase in p16 staining in benign/mildly atypical CBN () and moderately atypical CBN () but not severely atypical CBN was found compared to melanoma. Similar results were obtained when comparing these classes of CBN with malignant CBN. Compared to conventional nevi, benign/mildly and moderately atypical CBN had similar p16 staining, but a significant decrease in p16 was found in severely atypical CBN (). (c) Ki-67 was significantly lower in CBN of all levels of atypia compared to melanoma ().
