p16 Expression Is Lost in Severely Atypical Cellular Blue Nevi and Melanoma Compared to Conventional, Mildly, and Moderately Atypical Cellular Blue Nevi

Table 2

𝑃 values for comparison between CBN and melanoma for p16 and Ki-67 staining.

CBN versus melanoma; (𝑁=12)	p16 intensity	% melanocytes stained; with p16	% melanocytes stained; with Ki-67
All CBN (𝑁=15)	0.023	0.001	0.019
Benign/mildly atypical CBN (𝑁=6)	0.001	0.0002	0.019
Benign/mildly/moderately atypical CBN (𝑁=10)	0.001	0.000009	0.017
Moderately atypical CBN (𝑁=4)	0.026	0.015	0.015
Moderately/severely atypical CBN (𝑁=9)	0.191	0.061	0.018
Severely atypical CBN (𝑁=5)	0.913	0.658	0.024