Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats

Figure 5

Histological appearances of colonic tissues in rats (H&E staining; magnification ×10). (a) Normal intact mucosa from Sham animals showed intact epithelial surface. (b) Colitis induced by acetic acid in control group: crypt damage, mucosal layers destruction, and leukocyte infiltration are evident. (c) acetic acid-induced colitis in reserpinised (6 mg/kg, i.p.) depressed rat, showing massive necrotic destruction of epithelium. (d, g, and h) Colitis tissue treated with dexamethasone (1 mg/kg, i.p.), maprotiline (20 mg/kg, i.p.), and maprotiline (40 mg/kg, i.p.) in nondepressed rats, respectively. (e, f) Colitis tissue treated with maprotiline (20 mg/kg, i.p.) and maprotiline (40 mg/kg, i.p.) in reserpinised (6 mg/kg, i.p.) depressed rats, showing attenuated the extent and severity of the histological signs of cell damage. i.p. = intraperitoneally.

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