Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats
Table 3
Effect of maprotiline (Map. 10, 20, and 40 mg/kg, i.p.) on pathologic parameters of colitis induced by acetic acid in normal and reserpinised (6 mg/kg, i.p.) depressed rats.
Groups
Inflammation severity (0–3)
Inflammation extent (0–3)
Crypt damage (0–4)
Total colitis index (0–10)
Sham
0 (0-0)
0 (0-0)
0 (0-0)
0 (0-0)
Control
3 (2-3)
3 (2-3)
4 (1–4)
9.5 (6–10)
Dex. 1
0.5 (0-1)
0 (0–2)
0 (0–2)
1 (0–5)
Map. 10
2 (0–3)
2.5 (0–3)
3 (0–4)
7.5 (0–9)
Map. 20
1 (0-1)
1 (0–2)
1 (0-1)
3 (0–4)
Map. 40
1 (0-1)
1 (0–2)
0 (0-0)
2 (0–3)
RSP
3 (1–3)
3 (1–3)
4 (1–4)
10 (4–10)
RMAP10
2.5 (1–3)
2 (1–3)
3 (0–4)
7.5 (2–10)
RMAP20
1 (1-1)
1 (0–2)
1.5 (0-0)
4.5 (1–3)
RMAP40
1 (0–3)
1 (0–3)
0.5 (0-1)
3 (0–7)
Dex. 1: dexamethasone (1 mg/kg), RSP: reserpine (6 mg/kg), i.p.: intraperitoneally. Values are presented as median (range) of six rats in each group. , compared to control; Mann-Whitney test.
