Table 2: Results of 1H 1D NMR analysis of aqueous extracts from lung tissue specimens. The relative concentration of metabolites is expressed as percentage fraction of the peak integral over the total spectrum integral. Each peak integral (singlet or multiplet) is obtained by curve fitting and is corrected for the number of protons. The confidence limits are calculated from fitting residual (see Materials and Methods section, Equation (1)). In some cases more than one peak for metabolite is unequivocally assigned; therefore, the associated concentration values are reported.

Metabolite Broncho pulmonary sequestrationBronchogenic cyst
Congenital lobar emphysema Control lung
(% fraction of total spectrum area)(% fraction of total spectrum area)(% fraction of total spectrum area)(% fraction of total spectrum area)

Lactic acid2.71 ± 0.023.09 ± 0.023.40 ± 0.024.42 ± 0.04
Alanine0.402 ± 0.0030.458 ± 0.0030.806 ± 0.0050.319 ± 0.003
Glutamic acid0.576 ± 0.0050.798 ± 0.0051.093 ± 0.0070.620 ± 0.006
Succinic acid0.0721 ± 0.00060.0504 ± 0.00030.0349 ± 0.00020.189 ± 0.002
Creatine0.1498 ± 0.00080.260 ± 0.0010.1788 ± 0.00090.182 ± 0.001
Choline0.0768 ± 0.00040.1079 ± 0.00050.279 ± 0.0010.0718 ± 0.0004
Phosphocholine0.0827 ± 0.00050.1063 ± 0.00050.1883 ± 0.0009ND
Glycerophosphocholine0.0744 ± 0.0004ND0.1145 ± 0.0006ND
Glucose beta0.0433 ± 0.00020.790 ± 0.0040.324 ± 0.0021.143 ± 0.007
Myoinositol1.019 ± 0.0061.137 ± 0.0051.364 ± 0.0070.522 ± 0.003
Creatine0.192 ± 0.0010.311 ± 0.0010.223 ± 0.0010.170 ± 0.001
Myoinositol_b0.847 ± 0.0051.371 ± 0.0071.932 ± 0.0090.472 ± 0.003
Formic acid1.5 ± 0.10.23 ± 0.020.10 ± 0.010.42 ± 0.02