Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats

Table 1

Effect of MEIF graded dose on INH-induced convulsion in rats.

Treatments dose			Number convulsed/number used	% Animals protected	Latency of tonic convulsion (min); (mean ± SEM)
INH; (mg/kg, i.p.)	Diazepam (mg/kg, i.p.)	MEIF (mg/kg, p.o.)
250	—	—	6/6	0	13.20 ± 1.00
250	—	100	5/6	16.67	17.04 ± 0.59
250	—	200	3/6	50	20.55 ± 0.80^a
250	—	400	1/6	83.33	27.75 ± 2.55^abc
250	1.0	—	0/6	100	∞^a

Values are expressed as mean ± SEM ( = 6). Statistical comparison was analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. ^a < 0.05, statistically significant as compared to negative control; ^b < 0.05, statistically significant as compared to MIEF (100 mg/kg, p.o.); ^c < 0.05, statistically significant as compared to MEIF (200 mg/kg, p.o.).