Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats

Table 2

Effect of MEIF graded dose on GABA and glutamate level in brain homogenate.

Treatments dose			GABA (µg/mg protein)	Glutamate (μg/mg protein)
INH (mg/kg, i.p.)	Diazepam (mg/kg, i.p.)	MEIF (mg/kg, p.o.)
—	—	—	33.13 ± 1.22	52.38 ± 1.57
250	—	—	10.21 ± 0.92^a	126.27 ± 15.25^a
250	1.0	—	25.17 ± 3.96^b	66.63 ± 1.20^b
250	—	100	15.63 ± 3.50^a	105.15 ± 10.49^ac
250	—	200	24.01 ± 3.71^b	82.58 ± 4.65^b
250	—	400	25.60 ± 1.16^b	74.67 ± 3.23^b

Values are expressed as mean ± SEM ( = 6). Statistical comparison was analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. ^a < 0.05, statistically significant as compared to normal control; ^b < 0.05, statistically significant as compared to negative control (INH); ^c < 0.05, statistically significant as compared to diazepam 1.0 mg/kg, i.p.