Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats

Table 3

Effect of MEIF graded dose on pentylenetetrazole- (PTZ-) induced convulsion in rats.

Treatments dose			Number convulsed/number used	% Animals protected	Latency of tonic convulsion (min); (mean ± SEM)
PTZ; (mg/kg, i.p.)	Vigabatrin (mg/kg, i.p.)	MEIF (mg/kg, p.o.)
90	—	—	6/6	0	10.7 ± 0.34
90	—	100	5/6	16.67	12.2 ± 0.41
90	—	200	4/6	33.33	13.0 ± 0.55^a
90	—	400	0/6	66.67	16.6 ± 0.65^abc
90	50	—	0/6	100	∞^a

Values are expressed as mean ± SEM ( = 6). Statistical comparison was analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. ^a < 0.05, statistically significant as compared to negative control; ^b < 0.05, statistically significant as compared to MIEF (100 mg/kg, p.o.); ^c < 0.05, statistically significant as compared to MEIF (200 mg/kg, p.o.).