Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats

Table 4

Effect of MEIF graded dose on pentylenetetrazole- (PTZ-) induced convulsion in rats.

Treatments dose			LPO; (nmole MDA/g brain tissue)	SOD; (unit/g brain tissue)	CAT; (unit/g brain tissue)	GSH; (μg/g brain tissue)
PTZ; (mg/kg, i.p.)	Vigabatrin; (mg/kg, i.p.)	MEIF; (mg/kg, p.o.)
—	—	—	20.12 ± 0.82	30.53 ± 0.48	25.02 ± 0.65	256.4 ± 19.24
90	—	—	52.87 ± 0.96^a	15.13 ± 3.03^a	11.47 ± 1.12^a	121.02 ± 14.20^a
90	50	—	23.17 ± 1.83^b	26.70 ± 1.92^b	23.14 ± 1.30^b	242.0 ± 11.98^b
90	—	100	43.29 ± 2.72^abc	18.27 ± 1.71^a	15.35 ± 0.83^ac	192.57 ± 12.75^b
90	—	200	38.62 ± 2.81^abc	21.56 ± 2.35^a	19.85 ± 0.76^abd	218.90 ± 17.80^b
90	—	400	28.28 ± 2.2^bde	25.75 ± 1.60^b	21.73 ± 1.02^bd	235.86 ± 13.31^b

Values are expressed as mean ± SEM ( = 6). Statistical comparison was analyzed by one-way ANOVA followed by Tukey’s multiple comparison test. ^a < 0.05, statistically significant as compared to normal control; ^b < 0.05, statistically significant as compared to negative control (PTZ 90); ^c < 0.05, statistically significant as compared to standard vigabatrin (50 mg/kg, i.p.); ^d < 0.05, statistically significant as compared to MEIF (100 mg/kg, p.o.); ^e < 0.05, statistically significant as compared to MEIF (200 mg/kg, p.o.).