Validation of a Stability-Indicating RP-HPLC Method for Determination of L-Carnitine in Tablets

Figure 3

Typical chromatograms of L-carnitine after degradation under (a) photolytic condition; (b) oxidative condition: peak 4 = hydrogen peroxide; (c) basic hydrolysis; peak 3 = unknown impurity (d); acidic hydrolysis: peak 3 = unknown impurity, peak 2 = Impurity A; (e) heat condition; and (f) L-carnitine working standard solution (1355.80 µg/mL) Peak 1 = L-carnitine, and peak 5 = tartaric acid.

(a)

(b)

(c)

(d)

(e)

(f)