Research Article
Validation of a Stability-Indicating RP-HPLC Method for Determination of L-Carnitine in Tablets
Table 1
Summary of stress degradation studies of L-carnitine.
| Stress condition/media/duration | Recovered L-carnitine (%) mean (RSD, %) | Number of observed impurities |
| Photolytic/H2O/254 nm/4 h | 99.50 (0.63) | 0 | Acidic/1.0 N HCl/70°C/12 h | 24.00 (0.81) | 2 | Neutral/H2O/70°C/12 h | 93.09 (1.93) | 0 | Oxidative/3.0% H2O2/4 h | 100.17 (1.28) | 0 | Basic/1.0 N NaOH/70°C/12 h | 17.35 (1.72) | 1 |
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