Validation of a Stability-Indicating RP-HPLC Method for Determination of L-Carnitine in Tablets

Table 1

Summary of stress degradation studies of L-carnitine.

Stress condition/media/duration	Recovered L-carnitine (%) mean (RSD, %)	Number of observed impurities
Photolytic/H2O/254 nm/4 h	99.50 (0.63)	0
Acidic/1.0 N HCl/70°C/12 h	24.00 (0.81)	2
Neutral/H2O/70°C/12 h	93.09 (1.93)	0
Oxidative/3.0% H2O2/4 h	100.17 (1.28)	0
Basic/1.0 N NaOH/70°C/12 h	17.35 (1.72)	1