Increasing Prevalence, Changes in Diagnostic Criteria, and Nutritional Risk Factors for Autism Spectrum Disorders

Table 3

Sensitivity and specificity of DSM-IV-TR, proposed DSM-5, and modified criteria for clinical diagnosis and empirically derived classifications*.

	Clinical ASD diagnosis		Empirically derived classifications
	Sensitivity	Specificity	Sensitivity	Specificity
DSM-IV-TR	0.95	0.86	0.92	0.83
DSM-5: field trial phase I	0.81	0.97	0.78	0.95
DSM-5: relaxed algorithm	0.93	0.95	0.89	0.92
DSM-5: without high-functioning symptoms	0.64	0.98	0.61	0.97
DSM-5: without sensory sensitivity/interests	0.78	0.97	0.75	0.96
DSM-5: one symptom per criterion	0.96	0.90	0.92	0.87

Comparison of DSM-IV-TR and proposed DSM-5 criteria was done using a subsample with complete data on the Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) (𝑁 = 6,426).
*Adapted from Frazier et al. [6].