Molecular and Cellular Pathways of Immunoglobulin G Activity In Vivo
Figure 1
Family of FcγRs and FcγR signaling pathways. (a) Shown is the family of mouse and human Fcγ-receptors, which can be distinguished with respect to their capacity to interact either with monomeric IgG or with multimeric immune complexes. Apart from the family of classical Fcγ-receptors, members of the C-type lectin family have been shown to bind to select IgG glycoforms. See text for further details. (b) Depicted are the signaling pathways triggered upon binding of immune complexes to FcγRIII on innate immune effector cells. Upon FcγRIII crosslinking, the ITAM motif in the common FcRγ-chain becomes phosphorylated, thereby creating docking sites for Syk which is responsible for triggering downstream signaling events. See text for further details.
