The Region Centromeric to HLA-C Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis

Table 1

Major polymorphic variants found in this study in patients with psoriasis (PsO) and psoriatic arthritis (PsA).

Marker	PsO 𝑛=50	Controls 𝑛=110	𝑃 values	PsA 𝑛=110	Controls 𝑛=110	𝑃 values
𝐻𝐿𝐴-𝐶^∗06	25 (50%)	19 (17%)	<0.00001^a	62 (56.4%)	19 (17%)	<0.00001^e
MICA-A9	15 (30%)	33 (30%)	NS	66 (60%)	33 (30%)	<0.00001^f
MICA-A5.1	18 (36%)	44 (40%)	NS	38 (34.5%)	44 (40%)	NS
MICB-CA20	5 (10%)	9 (8.1%)	NS	15 (13.6%)	9 (8.1%)	NS
𝐻𝐿𝐴-𝐷𝑅𝐵1^∗07	15 (30%)	33 (30%)	NS	43 (39.1%)	33 (30%)	NS
𝐻𝐿𝐴-𝐵^∗27	5 (10%)	8 (7.3%)	NS	36 (32.7%)	8 (7.3%)	0.001^g
C1_4_4 (384)	28 (56%)	25 (23%)	0.0001^b	60 (54.5%)	25 (23%)	0.0001^h
OTF3 Hind3	42 (84%)	66 (60%)	0.0033^c	73 (66.4%)	66 (60%)	NS
HCR (Pg8)	31 (62%)	28 (25.5%)	<0.00001^d	37 (33.6%)	28 (25.5%)	NS

aOR 4.8 (2.3–10.1).
bOR 4.3 (2.1–8.8).
cOR 3.5 (1.5–8.01).
dOR 4.8 (2.3–9.7).
eOR 6.18 (3.32–11.51).
fOR 3.5 (2.0–6.12).
gOR 5.9 (2.6–13.4).
hOR 4.3 (2.2–8.4).
There was linkage disequilibrium between 𝐻𝐿𝐴-𝐶^∗06 and C1_4_4 (𝜆𝑠=0.6).