Intravesical Liposome and Antisense Treatment for Detrusor Overactivity and Interstitial Cystitis/Painful Bladder Syndrome

Figure 4

Illustration of mechanisms for blocking NGF expression by either NGF antibodies or downregulation of NGF mRNA expression. NGF antibody sequesters the freely available NGF and prevents it from binding with the cognate TrkA receptors. NGF antisense selectively binds with NGF mRNA inside the cells to block the translation of corresponding mRNA. siRNA takes advantage of endogenous cellular pathways to degrade NGF mRNA and control the posttranscriptional NGF gene expression.