Research Article
Study of the Effect of Dillenia indica Fruit Mucilage on the Properties of Metformin Hydrochloride Loaded Spray Dried Microspheres
Table 2
In vitro evaluation of the metformin hydrochloride loaded spray dried microspheres prepared using mucilage of D. indica.
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Formulation code |
Mean particle size (µm) ± SD; = 80 |
Drug entrapment efficiency (%) ± SD; | Liquid uptake capacity in different media (%) ± SD; = 3 | 0.1 M HCl | Water | Phosphate buffer (pH 7.4) |
| SD1 | 62 ± 4.09 | 43.67 ± 0.58 | 12 ± 1.22 | 26 ± 0.39 | 42 ± 1.07 | SD2 | 69 ± 2.34 | 44.02 ± 1.05 | 16 ± 0.55 | 32 ± 0.60 | 44 ± 0.66 | SD3 | 78 ± 4.24 | 47.05 ± 2.01 | 20 ± 0.74 | 48 ± 0.62 | 48 ± 0.23 | SD4 | 76 ± 3.58 | 43.74 ± 1.24 | 10 ± 0.82 | 22 ± 0.22 | 42 ± 0.08 | SD5 | 77 ± 1.08 | 45.13 ± 0.83 | 12 ± 0.19 | 16 ± 0.23 | 43 ± 0.26 | SD6 | 85 ± 4.06 | 49.84 ± 1.68 | 28 ± 0.41 | 50 ± 0.39 | 54 ± 0.14 | SD7 | 83 ± 3.34 | 44.78 ± 1.09 | 12 ± 0.34 | 42 ± 0.42 | 52 ± 0.22 | SD8 | 84 ± 2.18 | 46.03 ± 2.01 | 28 ± 0.29 | 24 ± 0.37 | 57 ± 0.14 | SD9 | 93 ± 3.87 | 53.17 ± 1.06 | 18 ± 0.25 | 52 ± 0.11 | 62 ± 0.92 | SD10 | 78 ± 3.47 | 47.33 ± 1.57 | 17 ± 0.25 | 22 ± 0.53 | 48 ± 0.55 | SD11 | 85 ± 2.11 | 52.73 ± 1.23 | 11 ± 0.24 | 18 ± 0.62 | 45 ± 0.64 | SD12 | 98 ± 4.13 | 55.12 ± 1.83 | 28 ± 0.14 | 54 ± 0.13 | 66 ± 0.05 |
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