Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction

Table 1

Results of anti-inflammatory activity of 4-aminoantipyrine derivatives 4(a–h).

Test Compds	Increase in paw volume at different time interval (h)^a					% inhibition
	150 mg/kg
	0	1	2	3	4
Control	0.32 ± 0.03	0.58 ± 0.02	0.83 ± 0.05	1.96 ± 0.01*	2.15 ± 0.04	—
4a	0.33 ± 0.02*	0.59 ± 0.01	0.80 ± 0.05*	0.78 ± 0.03	0.74 ± 0.01	47.27
4b	0.33 ± 0.05	0.56 ± 0.02	0.78 ± 0.03	0.77 ± 0.03	0.71 ± 0.03*	49.10
4c	0.30 ± 0.04*	0.47 ± 0.03	0.49 ± 0.02	0.34 ± 0.05*	0.33 ± 0.02	78.91
4d	0.31 ± 0.02*	0.47 ± 0.04	0.45 ± 0.01	0.37 ± 0.02	0.31 ± 0.03	74.82
4e	0.31 ± 0.05	0.42 ± 0.01*	0.46 ± 0.03	0.34 ± 0.02	0.32 ± 0.03*	72.73
4f	0.30 ± 0.04*	0.36 ± 0.04	0.42 ± 0.05	0.33 ± 0.01*	0.31 ± 0.04	74.55
4g	0.32 ± 0.05	0.54 ± 0.03*	0.66 ± 0.02*	0.49 ± 0.04	0.44 ± 0.01*	61.82
4h	0.30 ± 0.03	0.34 ± 0.01*	0.41 ± 0.05*	0.33 ± 0.04	0.31 ± 0.05*	76.45
Diclofenac (10 mg/kg)	0.30 ± 0.01	0.31 ± 0.03	0.33 ± 0.05*	0.12 ± 0.04	0.10 ± 0.02*	80.45

∗Significantly different from control at 𝑃<0.05.
^aResults are expressed as mean ± SEM.