Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction
Table 2
Results of anthelmintic activity of 4-aminoantipyrine derivatives 4(a–h).
Test Compds
12.5 mg/mL
25 mg/mL
50 mg/mL
100 mg/mL
150 mg/mL
Time of paralysis (min.)
Time of death (min.)
Time of paralysis (min.)
Time of death (min.)
Time of paralysis (min.)
Time of death (min.)
Time of paralysis (min.)
Time of death (min.)
Time of paralysis (min.)
Time of death (min.)
Control
—
—
—
—
—
—
—
—
—
—
ALB
21 ± 0.6
22 ± 0.5
18 ± 0.4*
19 ± 0.6
15 ± 1.0
17 ± 0.8
13 ± 1.2
14 ± 0.6*
10 ± 0.5
10 ± 1.8*
4a
22 ± 1.4
23 ± 0.5
19 ± 1.5
20 ± 0.7*
16 ± 1.0
17 ± 0.6
14 ± 0.7*
15 ± 1.3*
11 ± 0.5
11 ± 1.0*
4b
23 ± 1.5
23 ± 1.3*
20 ± 2.1*
21 ± 2.3
18 ± 1.2
20 ± 1.0
15 ± 1.2*
16 ± 1.7
12 ± 0.5
12 ± 0.3
4c
30 ± 0.6
31 ± 0.5*
28 ± 1.3
29 ± 1.0*
26 ± 0.7*
27 ± 0.9
22 ± 0.5
23 ± 0.7
20 ± 1.2*
19 ± 0.7
4d
39 ± 0.9
42 ± 1.5
37 ± 1.4
40 ± 1.2
35 ± 1.3
35 ± 1.2
33 ± 0.6
34 ± 0.7
31 ± 0.8
32 ± 0.4
4e
24 ± 0.8*
24 ± 1.3
21 ± 1.3
22 ± 0.1*
17 ± 0.6
17 ± 1.6*
14 ± 0.7
15 ± 1.0
12 ± 0.8*
12 ± 0.2
4f
30 ± 1.0*
30 ± 0.6
29 ± 0.3
30 ± 1.0
27 ± 1.2
28 ± 0.6*
24 ± 0.5
25 ± 1.2
20 ± 1.5
21 ±1.2
4g
21 ± 0.4
23 ± 0.7
19 ± 0.3
19 ± 1.1
16 ± 1.0
17 ± 0.6
13 ± 1.7
14 ± 0.6*
12 ± 1.0
12 ± 1.2
4h
29 ± 0.3
30 ± 0.5
26 ± 1.3
27 ± 1.0
24 ± 0.2*
24 ± 0.6*
21 ± 0.7
22 ± 0.4
18 ± 1.0
19 ± 1.2*
Standard drug, Albendazole (ALB), was used at 10 mg/mL; “—” indicates absence of activity in 24 h of administration. *Significantly different from ALB at .
