Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

Table 6

Haemagglutination antibody titer: secondary antibody response.

Treatment	Dose (mg/kg)	Ovalbumin antigen		Tetanus toxoid antigen
			lgG2a	lgG1	LgG2a
Ethanol extract	200	^*0.47 ± 0.017	^*0.21 ± 0.035	^*0.11 ± 0.015	^*0.11 ± 0.012
	400	^*0.46 ± 0.014	^*0.21 ± 0.023	^*0.16 ± 0.018	^*0.23 ± 0.014
Ethyl acetate fraction	200	^*0.49 ± 0.017	^*0.15 ± 0.012	^*0.15 ± 0.013	^*0.17 ± 0.010
	400	^*0.34 ± 0.013	^*0.14 ± 0.010	^*0.15 ± 0.011	^*0.15 ± 0.009
Methanol fraction	200	^*0.50 ± 0.013	^*0.19 ± 0.013	^*0.15 ± 0.017	^*0.19 ± 0.011
	400	^*0.30 ± 0.010	^*0.17 ± 0.014	^*0.16 ± 0.018	^*0.12 ± 0.019
Noni capsule	50	^*1.10 ± 0.036	^*0.99 ± 0.045	^*0.86 ± 0.037	^*0.73 ± 0.013
Normal saline	10 mL/kg	0.08 ± 0.001	0.05 ± 0.007	0.04 ± 0.006	0.03 ± 0.005

= 5, P < 0.01.