Review Article

Cytoskeleton and Adhesion in Myogenesis

Figure 1

Schematic view of skeletal myogenic steps, focusing on the cytoskeleton. A round, mononucleated cell has short actin filaments in the cortex, dispersed intermediate filaments, and radial microtubules. After replication, myoblasts align with each other, and their actin filament begins to form the myofibrils, anchored in adhesion regions that connect to the extracellular matrix. After fusion, the differentiated myotubes are multinucleated and have strong myofibrils. The intermediate filaments are present around Z-lines (among other regions), and microtubules have no single organizing center. For color scheme, see Figure 4.
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