Hyaluronan Is Not a Ligand but a Regulator of Toll-Like Receptor Signaling in Mesangial Cells: Role of Extracellular Matrix in Innate Immunity
Figure 7
Effect of hyaluronidase and heparin on the specific stimulation of TLR3. (a, b) pMC/TLR4−/− cells types were incubated with different concentrations of a specific TLR3 ligand with and without hyaluronidase to demonstrate the effect of hyaluronidase on TLR stimulation. (c) Finally, the influence of heparin on the coincubation with hyaluronidase and TLR3 ligand was tested. Poly: Poly(I:C); HYAL: hyaluronidase; HEP: heparin; data are means ± SD, ns: not significant, .
