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ISRN Analytical Chemistry
Volume 2014 (2014), Article ID 816012, 9 pages
http://dx.doi.org/10.1155/2014/816012
Research Article

Electrooxidation of Indomethacin at Multiwalled Carbon Nanotubes-Modified GCE and Its Determination in Pharmaceutical Dosage Form and Human Biological Fluids

Post Graduate Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India

Received 31 December 2013; Accepted 19 February 2014; Published 30 March 2014

Academic Editors: A. Amine and S. Girousi

Copyright © 2014 Sanjeevaraddi R. Sataraddi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, rapid, selective, and sensitive electrochemical method for the direct determination of indomethacin was developed. The electrochemical behavior of indomethacin was carried at multiwalled carbon nanotube- (MWCNTs-) modified glassy carbon electrode (GCE). The cyclic voltammetric results indicated that MWCNT-modified glassy carbon electrode remarkably enhanced electrocatalytic activity towards the oxidation of indomethacin in slightly acidic solutions. It led to a considerable improvement of the anodic peak current for indomethacin and could effectively accumulate at this electrode and produce two anodic peaks at 0.720 V and 0.991 V, respectively, and one reduction peak at 0.183 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the determination of indomethacin by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.2 to 6.0  M and 13.2 nM, respectively. The proposed method was successfully applied to determination of Indomethacine in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.