The Wide and Complex Field of NAFLD Biomarker Research: Trends

Table 2

Overview of included studies with numbers of their cohorts and size, and statistical methodology [12–30, 41–83]. Reported results were displayed in mean or median. Cohorts below 60 subjects were included due to (1) overall many probands, (2) rare observed parameters, for example, CCT, AP, insulin, ferritin, and adiponectin, (3) small study because of small infrastructure of this country (e.g., European studies), and (4) rare documented diabetic probands of NAFLD studies.

Study	Total number of included cohorts of each study	Number of subjects of the smallest included cohort	Number of subjects of the largest included cohort	M: median; A: mean; MA: mean and median mixed	Remarks to studies with smaller cohorts than 60 subjects
Sun and Lü 2011 [72]	2	234	248	A
Yasui et al., 2011 [71]	2	82	92	M
Lee et al., 2010 [30]	3	1242	1276	A
Xu et al., 2010 [29]	6	814	6077	MA
Hwang et al., 2011 [28]	2	1613	3019	A
Arase et al., 2011 [27]	1	5561	NA	A
Thiruvagounder et al., 2010 [26]	4	61	76	A
Xu et al., 2011 [25]	2	227	651	MA
Tan et al., 2010 [70]	3	51	135	A	1
Caserta et al., 2010 [69]	2	74	498	M
Ferreira et al., 2010 [68]	2	33	45	A	2
Park et al., 2011 [63]	2	145	311	A
Sentinelli et al., 2011 [67]	2	239	346	M
Kaelsch et al., 2011 [66]	2	56	71	A	1
de Luis et al., 2010 [21]	2	15	68	A	3
Alkhouri et al., 2010 [65]	3	11	36	MA	3
Barchetta et al., 2011 [64]	2	100	162	A
Esteghamati et al., 2010 [62]	6	94	576	A
Gupta et al., 2011 [61]	2	98	280	MA
Kirovski et al., 2010 [60]	2	62	93	A
Raszeja-Wyszomirska et al., 2010 [20]	2	14	48	A	3
Lee et al., 2010 [59]	2	24	25	A	2
Kilciler et al., 2010 [19]	2	54	60	MA	1, 3
Abdelmalek et al., 2010 [24]	2	84	224	A
Qureshi et al., 2010 [58]	3	26	58	A	2
Adams et al., 2010 [57]	2	116	221	A
Dongiovanni et al., 2010 [56]	2	202	346	A
Harte et al., 2010 [18]	2	23	155	A	3
Younossi et al., 2011 [55]	2	39	40	A	2
Narciso-Schiavon et al., 2010 [53]	2	38	56	A	2
Oh et al., 2011 [48]	10	39	358	MA	1, 2
Söderberg et al., 2011 [17]	6	3	12	A	3
Tragher 2011	2	161	182	MA
Aigner et al., 2010 [16]	2	27	124	A	3
García-Monzón et al., 2011 [15]	3	24	29	A	3
Neuschwander-Tetri et al., 2010 [23]	2	291	404	M
Firneisz et al., 2010 [14]	3	23	82	A	3
Sumida et al., 2011 [51]	2	198	244	A
Eguchi et al., 2011 [50]	3	74	375	A
Ulitsky et al., 2010 [49]	2	52	201	A	1, 2
Williams et al., 2011 [48]	2	40	89	A	1, 2
Sokooian S 2010	3	45	102	A	1, 2
Hotta et al., 2010 [46]	4	64	578	A
Tapan et al., 2010 [45]	2	31	65	MA
Sokooian S 2010	2	102	188	A	2
Aller et al., 2010 [13]	2	15	51	A	3
Fierbinteanu-Braticevici et al., 2011 [12]	2	42	45	M	3
Rodriguez-Hernandez et al., 2010 [43]	4	29	229	A	4
Suzuki et al., 2010 [42]	2	22	62	A	2
Kalhan et al., 2011 [41]	3	11	25	A	2
Souza-Oliveira CPM 2010	2	45	86	A	2
Manousou et al., 2011 [22]	4	24	64	A	1, 3
Park et al., 2010 [82]	1	66	NA	A
Sumida Y 2010	4	43	399	A	1, 2
Tanaka et al., 2011 [74]	1	55	NA	M
Brunt et al., 2011 [80]	3	183	543	M
Raszeja-Wyszomirska J 2010	1	104	NA	A
Baba et al., 2011 [73]	1	165	NA	A
Yilmaz Y 2010	2	56	58	A	1
Tsutsui et al., 2010 [77]	1	105	NA	A
Verrijken et al., 2010 [76]	1	367	NA	A
Akyildiz et al., 2010 [75]	2	91	104	A
These 62 included articles contain  45 228 subjects of 157 cohorts				A  =  75,8%; M  =  11,3%; MA  =  12,8%