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ISRN Otolaryngology
Volume 2014 (2014), Article ID 859621, 7 pages
http://dx.doi.org/10.1155/2014/859621
Research Article

Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch

Laboratório de Biologia Celular e Tecidual, Faculdade de Biociências, PUCRS, Avenida Ipiranga 6681, Prédio 12, Sala 104, 90619-900 Porto Alegre, RS, Brazil

Received 5 December 2013; Accepted 6 January 2014; Published 13 February 2014

Academic Editors: S. Y. Kwon, D. Thurnher, and S. C. Winter

Copyright © 2014 Fernanda Lopes de Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control—C , acetone—A , carbamide peroxide—CP , acetone and CP—A+CP , 1% DMBA in acetone and CP—DA+CP , and 1% DMBA in acetone and CP and 4-week treatment with sunitinib—DA+CP+S . The aspects evaluated were anatomopathological features (peribuccal area, paws, nose, and fur), histological sections of the hamster buccal pouches (qualitatively analyzed), epithelium thickness, and the rete ridge density (estimated). Sunitinib was unable to attenuate the decrease in weight gain induced by DMBA; no increase in volume was detected in the pouch and/or ulceration, observed in 43% of the animals in the DA+CP group. DA+CP groups presented a significant increase in rete ridge density compared to the control groups ( ) which was reverted by sunitinib in the DA+CP+S group. Sunitinib seems to have important benefits in early stage carcinogenesis and may be useful in chemoprevention.