Figure 12: Oral delivery of pDNA with GFP reporter in ALG microspheres in mice. (a) Flow cytometric analyses showing biodistribution reflected through %GFP-positive cells among various organs 24 and 48 h after the administration of 50 μg and 100 μg pDNA dose. Number of animals for each dose ; total number of . (b) Dose-response assessment showing %GFP-positive cells among various mice organs 24 h after the administration of 50 μg, 100 μg, and 150 μg dose. Number of animals for each dose (except for 150 μg-dose group which had only 3); total number of . All measurements were done in triplicates. Results represent error with the basal levels of expression from negative controls subtracted from expression levels observed in dosed groups. Reproduced from  with permission of Elsevier.