Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

Table 3

Effect of sonication time.

Sonication time	Particle size (nm)	Polydispersity index
5 min	178.4±0.65	0.381±0.02
10 min	133±1.6	0.316±0.09
15 min	102±1.3	0.296±0.03
20 min	99.7±0.9	0.242±0.02
25 min	98±1.0	0.222±0.31

Note. *Results are expressed as mean ± standard deviation (𝑛=3).