Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

Table 4

Summary of model statistics for dependent variables.

Model	Sum of squares	Degrees of freedom	Mean square	𝑅^2	Adjusted 𝑅^2	Predicted 𝑅^2	PRESS	s.d.	𝐹 value	𝑃 value; Prob > 𝐹	Remarks
Response 1 (particle size (nm))
Linear	15423.02	2	7711.51	0.2764	0.0352	−0.5608	87088.22	82.03	1.15	0.3789	Suggested
Interactive	183.60	1	183.60	0.2797	−0.1525	−1.6074	145485.1	89.66	0.02	0.8858
Quadratic	14921.87	2	7460.93	0.5471	−0.2076	−4.0030	279153.1	91.78	0.89	0.4985
Response 2 (zeta potential (mV))
Linear	48.6416667	2	24.32083333	0.1291044	—	−1.39076	900.7465	7.39505	0.44473	0.6605	Suggested
Interactive	170.3025	1	170.3025	0.5811203	0.329792	−0.68016	633.0196	5.61815	5.395533	0.0678
Quadratic	59.0561111	2	29.52805556	0.7378666	0.300978	−2.19533	1203.879	5.737652	0.896946	0.4951