Toxicity and Loss of Mitochondrial Membrane Potential Induced by Alkyl Gallates in Trypanosoma cruzi

Table 1

Antitrypanosomal activity of gallic acid (1) and n-alkyl gallates (2–14) against epimastigote forms of Trypanosoma cruzi. IC₅₀ values were expressed in M.

Compound	R		IC50
Gallic acid (1)	H	0.89	>100^b
Methyl gallate (2)	CH3	0.92	>100^b
Ethyl gallate (3)	CH2CH3	1.27	>100^b
Propyl gallate (4)	CH3	1.73	>100^b
Butyl gallate (5)	CH3	2.13	>100^b
Pentyl gallate (6)	CH3	2.53	>100^b
Hexyl gallate (7)	CH3	2.92	>100^b
Heptyl gallate (8)	CH3	3.32	37.3 ± 0.9
Octyl gallate (9)	CH3	3.72	23.0 ± 5.3
Nonyl gallate (10)	CH3	4.11	2.90 ± 0.1
Decyl gallate (11)	CH3	4.51	1.50 ± 0.3
Undecyl gallate (12)	CH3	4.90	1.46 ± 0.0
Dodecyl gallate (13)	CH3	5.30	2.13 ± 0.2
Tetradecyl gallate (14)	CH3	6.09	17.6 ± 1.8
Benznidazole^c	—	—	34.0

^aValues described by Rosso and coworkers (2006) [16].
^bPercentage of inhibition at 100 M.
^cPositive control.