International Scholarly Research Notices The latest articles from Hindawi Publishing Corporation © 2015 , Hindawi Publishing Corporation . All rights reserved. Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea Wed, 30 Sep 2015 13:11:39 +0000 Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson’s disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121 matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype () and of the G allele () in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea ( and , resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients. Anthony Karpouzis, Paschalis Avgeridis, Gregory Tripsianis, Elisavet Gatzidou, Niki Kourmouli, and Stavroula Veletza Copyright © 2015 Anthony Karpouzis et al. All rights reserved. Sensitivity Analysis and Validation for Numerical Simulation of Water Infiltration into Unsaturated Soil Mon, 28 Sep 2015 12:36:48 +0000 A FORTRAN code for liquid water flow in unsaturated soil under the isothermal condition was developed to simulate water infiltration into Yolo light clay. The governing equation, that is, Richards’ equation, was approximated by the finite-difference method. A normalized sensitivity coefficient was used in the sensitivity analysis of Richards’ equation. Normalized sensitivity coefficient was calculated using one-at-a-time (OAT) method and elementary effects (EE) method based on hydraulic functions for matric suction and hydraulic conductivity. Results from EE method provided additional insight into model input parameters, such as input parameter linearity and oscillating sign effect. Boundary volumetric water content ( (upper bound)) and saturated volumetric water content () were consistently found to be the most sensitive parameters corresponding to positive and negative relations, as given by the hydraulic functions. In addition, although initial volumetric water content ( (initial cond)) and time-step size (Δt), respectively, possessed a great amount of sensitivity coefficient and uncertainty value, they did not exhibit significant influence on model output as demonstrated by spatial discretization size (Δz). The input multiplication of parameters sensitivity coefficient and uncertainty value was found to affect the outcome of model simulation, in which parameter with the highest value was found to be Δz. Eng Giap Goh and Kosuke Noborio Copyright © 2015 Eng Giap Goh and Kosuke Noborio. All rights reserved. Enamel and Dentin Surface Finishing Influence on the Roughness and Microshear Bond Strength of a Lithium Silicate Glass-Ceramic for Laminate Veneers Mon, 07 Sep 2015 11:11:05 +0000 Objectives. This study evaluated the influence of cavity surface finishing with diamond burs of different grit mounted on high-speed turbine and ultrasound on the roughness and microshear bond strength (MBS) of a lithium silicate glass-ceramic to enamel and dentin. Methods. Enamel and dentin specimens were divided into seven groups, according to the type of surface finishing: 1200-grit sandpaper (control), two different brands of medium-grit and fine-grit diamond burs in a high-speed turbine; medium-grit and fine-grit CVD (chemical vapor deposition) tips in an ultrasonic device. Roughness parameters () and MSBS to a glass-ceramic () were determined. Data were analyzed using ANOVA and Tukey’s test ( = 5%). Results. Control group showed lower mean roughness readings and groups that used medium-grit diamond burs showed the highest mean roughness values. Regarding MSBS, there was no statistical difference when comparing the groups gritted with the same brand of medium- and fine-grit burs and tips. Conclusions. Cavity surface finishing influenced the roughness parameters and MSBS of a glass-ceramic to enamel and dentin. Medium-grit diamond burs in high-speed turbine showed the highest mean roughness values. Fine-grit CVD tips in ultrasound presented the highest MSBS values for both enamel and dentin. Carla Castiglia Gonzaga, Ruth Peggy Bravo, Thiago Vinícius Pavelski, Paula Pontes Garcia, Gisele Maria Correr, Denise Piotto Leonardi, Leonardo Fernandes da Cunha, and Adilson Yoshio Furuse Copyright © 2015 Carla Castiglia Gonzaga et al. All rights reserved. Evaluation of Discoloration Removal by Polishing Resin Composites Submitted to Staining in Different Drink Solutions Thu, 20 Aug 2015 14:20:34 +0000 The aim of this study was to evaluate the discoloration effects of water, cola-based soft drink, coffee, and wine on resin composites used in restorative dentistry and the possibility of removing the stain with chair side manual polishing. The A2 shade of three materials was tested. Disc specimens were prepared. A spectrophotometer was used to measure the baseline CIE-Lab color parameters of each material () 24 hours after sample preparation. Samples were then immersed in a cola-based soft drink, coffee, or wine for 1 hour every day, for 30 days. For the remaining hours, the specimens were stored in distilled water. In the control group, the specimens were immersed in water for the whole period. The color differences () were calculated after 7 and 30 days of storage, and after polishing with coarse Sof-Lex discs, and analyzed by two-way ANOVA with repeated measures and Tukey’s HSD test (). Luna presented higher values followed by Durafill and Herculite . For the drink solutions, values were higher for wine followed by coffee and for cola-based soft drink and water which were statistically similar. For time, values were higher for 30 days and then for 7 days and after polishing . The results indicate that color stability is material dependent. The types of drinks that patients consume also influence the color stability of restorative materials. Denis Roberto Falcão Spina, João Ricardo Almeida Grossi, Rafael Schlögel Cunali, Flares Baratto Filho, Leonardo Fernandes da Cunha, Carla Castiglia Gonzaga, and Gisele Maria Correr Copyright © 2015 Denis Roberto Falcão Spina et al. All rights reserved. Knowledge and Practice on Prevention of Respiratory Health Problems among Traffic Police in Kathmandu, Nepal Thu, 13 Aug 2015 13:32:44 +0000 Introduction. Traffic police in Kathmandu are continuously exposed to air pollution and are at an increased health risk. This study aimed to assess the knowledge and practice regarding prevention of respiratory problems among traffic police in Kathmandu. Methods. A descriptive exploratory study was conducted among the traffic police () working in six areas of the Kathmandu Metropolis from July to August 2013. Self-administered questionnaires were distributed to all the participants. Results. The mean age (±SD) of the respondents was 28.8 ± 4.3 years. More than half of the respondents had 6–10 years of work experience, the mean (±SD) years of experience being 7.9 (±3.6). The level of knowledge regarding the prevention of respiratory problems was better than the level of practice among the respondents. Education of the participants did not affect the level of practice of the respondents while there was association between working experience and level of practice (). Conclusion. Since the preventive practice is poor, the government should come up with plans such as distribution of antipollution masks to improve the level of practice among traffic police to prevent respiratory problems. Ambika Aryal Bhandari, Roshani Gautam, and Shiva Bhandari Copyright © 2015 Ambika Aryal Bhandari et al. All rights reserved. Retracted: A Survey of Home Delivery and Newborn Care Practices among Women in a Suburban Area of Western Nigeria Tue, 11 Aug 2015 06:32:45 +0000 International Scholarly Research Notices Copyright © 2015 International Scholarly Research Notices. All rights reserved. Black Plane Solutions and Localized Gravitational Energy Thu, 06 Aug 2015 11:53:26 +0000 We explore the issue of gravitational energy localization for static plane-symmetric solutions of the Einstein-Maxwell equations in 3+1 dimensions with asymptotic anti-de Sitter behavior. We apply three different energy-momentum complexes, the Einstein, Landau-Lifshitz, and Møller prescriptions, to the metric representing this category of solutions and determine the energy distribution for each. We find that the three prescriptions offer identical energy distributions, suggesting their utility for this type of model. Paul Halpern and Jennifer Roberts Copyright © 2015 Paul Halpern and Jennifer Roberts. All rights reserved. Effects of Curved Wavefronts on Conductor-Backed Reflection-Only Free-Space Material Characterization Techniques Wed, 15 Jul 2015 10:58:40 +0000 A true plane wave is often not physically realizable in a laboratory environment. Therefore, wavefront curvature introduces a form of systematic error into Free-space material characterization methods. Free-space material characterization is important to the determination of the electric permittivity and magnetic permeability of conductor-backed and in situ materials. This paper performs an error analysis of the impact on wavefront curvature on a Free-space method called the two-thickness method. This paper compares the extracted electric and magnetic permeability computed with a plane wave versus a line source for a low-loss dielectric and magnetic radar absorbing material. These steps are conducted for TE and TM plane waves and electric and magnetic line sources. Raenita A. Fenner and Edward J. Rothwell Copyright © 2015 Raenita A. Fenner and Edward J. Rothwell. All rights reserved. Effect of Nano-Tricalcium Phosphate and Nanohydroxyapatite on the Staining Susceptibility of Bleached Enamel Sun, 05 Jul 2015 10:52:27 +0000 Objective. This study was designed to evaluate the effect of nano-tricalcium phosphate (n-TCP) and nanohydroxyapatite (n-HAP) on prevention of restaining of enamel after dental bleaching. Methods. Forty bovine incisors were bleached with 20% carbamide peroxide for two weeks. Afterward, they were divided into five groups based on remineralization solution: no treatment (control), 10% n-TCP, 5% n-TCP, 10% n-HAP, and 5% n-HAP. Each group was daily immersed for 10 minutes in the restaining solution (tea) and for 3 minutes in the remineralization agent, respectively. This protocol was repeated for five days. Subsequently, three digital photographs (baseline, after bleaching, and after restaining) were analyzed by Adobe Photoshop software. The obtained , , , and parameters were compared using ANOVA and Wilcoxon and Bonferroni tests. Results. After bleaching, there were significant changes in tooth colors () while, after restaining and immersion in remineralization solutions, there were no significant differences in , , and values of different groups (). However, of 10% TCP was significantly lower than the control () while there were no significant differences between the other groups (). Conclusion. 10% n-TCP could significantly maintain the resultant color and reconstruct the enamel structure after bleaching. Mohammad Bagher Rezvani, Mohammad Atai, Mohammad Reza Rouhollahi, Kosar Malekhoseini, Hamideh Rezai, and Faeze Hamze Copyright © 2015 Mohammad Bagher Rezvani et al. All rights reserved. Outcome-Based Quality Control by a Dental Reference Profile of a Population-Based Study (SHIP-0) Thu, 02 Jul 2015 12:19:15 +0000 Objectives. The aim was to develop an instrument for quality control in dental practices. We compared the number of teeth of subjects of the Study of Health in Pomerania (SHIP-0) with those from patients of dental practices. Methods. Patients from seven dental practices were randomly sampled by age strata and gender for a period of two years. Dental status derived from patient files was transformed into practice profiles using age-specific number of teeth as a parameter. Practice profiles were compared with a nomogram, which was based on the age-specific number of teeth of 3,990 SHIP-0 participants regularly visiting the dentist. Further, negative binomial regression models were evaluated to model associations between the number of teeth with age and dental practices, including interactions. Results. The practice profiles ranged between the 45th and 95th quantile curves of the reference population SHIP-0. The rate ratios (RR) for the number of missing teeth ranged from 0.37 to 0.67 between the different dental practices, indicating lower risk for higher numbers of missing teeth in comparison to SHIP-0. Conclusions. This study showed considerable differences between dental practices and the reference population of SHIP-0 regarding the pattern of tooth loss and confirms the value of nomograms to compare age-specific numbers of teeth between patients of dental practices and a population-based-study as a tool for quality control. For further analyses, the socioeconomic status of patients and relevant risk factors will be used to adjust for structural differences in order to improve the validity of the comparisons. Stefanie Samietz, Andreas Söhnel, Christian Schwahn, Birte Holtfreter, Torsten Mundt, Peter Meisel, Wolfgang Hoffmann, Thomas Kocher, and Reiner Biffar Copyright © 2015 Stefanie Samietz et al. All rights reserved. Design, Repeatability, and Comparison to Literature Data of a New Noninvasive Device Called “Rotameter” to Measure Rotational Knee Laxity Sun, 28 Jun 2015 14:42:39 +0000 The present paper deals with the design, the repeatability, and the comparison to literature data of a new measuring device called “Rotameter” to characterize the rotational knee laxity or the tibia-femoral rotation (TFR). The initial prototype P1 of the Rotameter is shortly introduced and then modified according to trials carried out on a prosthetic leg and on five healthy volunteers, leading therefore to an improved prototype P2. A comparison of results obtained from P1 and P2 with the same male subject shows the enhancements of P2. Intertester and intratester repeatability of this new device were shown and it was observed that rotational laxities of left and right knees are the same for a healthy subject. Moreover, a literature review showed that measurements with P2 presented lower TFR values than other noninvasive devices. The measured TFR versus torque characteristic was quite similar to other invasive devices, which are more difficult to use and harmful to the patient. Hence, our prototype P2 proved to be an easy-to-use and suitable device for quantifying rotational knee laxity. A forthcoming study will validate the Rotameter thanks to an approach based on computed tomography in order to evaluate its precision. Simon Neumann, Stefan Maas, Danièle Waldmann, Pierre-Louis Ricci, Arno Zürbes, Pierre-Jean Arnoux, and Jens Kelm Copyright © 2015 Simon Neumann et al. All rights reserved. High Risk Stage 2 and Stage 3 Colon Cancer, Predictors of Recurrence and Effect of Adjuvant Therapy in a Nonselected Population Sun, 21 Jun 2015 12:44:37 +0000 Patients with stage 2 and stage 3 colon cancer often are treated with adjuvant chemotherapy. However, patients seen in daily practice have more comorbidity than those enrolled in clinical trials. This study aims to evaluate prognostic factors for recurrence and to ascertain the benefit of adjuvant chemotherapy on recurrence-free survival (RFS) of patients in a nonselected population. Furthermore, the impact of relative dose intensity (RDI) of adjuvant therapy on RFS is examined. Chart review was performed for 243 consecutive patients diagnosed and treated at a single center for stage 2 and stage 3 colon cancer from 2002 to 2008. Adjuvant chemotherapy was administered to 66 patients. Median overall survival (OS) was 5.84 years and median RFS was 5.37 years. For stage 2 disease, patients treated with or without adjuvant therapy had a median RFS of 5.49 and 5.73, respectively ( = ns). For stage 3 disease, median RFS rates were 5.08 and 1.19, respectively (). Overall RDI of oxaliplatin based chemotherapy higher than median was associated with increased RFS (). In conclusion, adjuvant therapy did not significantly increase recurrence-free survival. This could be the result of comorbidity in patients. Relative dose intensity of oxaliplatin based therapy is associated with RFS. Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld Copyright © 2015 Elmer E. van Eeghen et al. All rights reserved. A Kinetic Model of Whole-Body Glucose Metabolism with Reference to the Domestic Dog (Canis lupus familiaris) Mon, 08 Jun 2015 13:35:50 +0000 A new two-pool model to describe glucose kinetics in the steady state is presented. The pools are plasma glucose, Q1, and tissue glucose, Q2 (both µmol). The flows (all µmol/min) into the plasma pool (Pool 1) are absorbed glucose entry from dietary sources, labelled glucose infusion, and hepatic glucose production. There is one flow out of Pool 1, glucose uptake by the tissues. Inflows to the tissues pool (Pool 2) are from plasma and glycogenolysis. Outflows from Pool 2 are to plasma, glucose oxidation, and glycogenesis and other metabolism. Application of the model was illustrated using experimental data derived from healthy adult Labrador Retrievers in the fasted and fed (repeated meal feeding) states. In general, model derived estimates of glucose kinetics were representative of normal glucose metabolism, where rates of glucose production and uptake are similar and act to maintain blood glucose concentrations. Furthermore, estimates of within tissue glucose cycling indicated glycogenolysis in fasting and glycogenesis when fed. In the fasted state, model outputs were consistent with those reported in the canine literature derived using a single pool model. Leslie L. McKnight, Anna K. Shoveller, Secundino Lopez, and James France Copyright © 2015 Leslie L. McKnight et al. All rights reserved. Corrigendum to “Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy” Sun, 31 May 2015 16:45:52 +0000 Tarek M. Moastafa, Alaa El-Din Elsayed El-Sissy, Gehan K. El-Saeed, and Mai Salah El-Din Koura Copyright © 2015 Tarek M. Moastafa et al. All rights reserved. Equivalent Air Spring Suspension Model for Quarter-Passive Model of Passenger Vehicles Sun, 31 May 2015 08:10:33 +0000 This paper investigates the GENSIS air spring suspension system equivalence to a passive suspension system. The SIMULINK simulation together with the OptiY optimization is used to obtain the air spring suspension model equivalent to passive suspension system, where the car body response difference from both systems with the same road profile inputs is used as the objective function for optimization (OptiY program). The parameters of air spring system such as initial pressure, volume of bag, length of surge pipe, diameter of surge pipe, and volume of reservoir are obtained from optimization. The simulation results show that the air spring suspension equivalent system can produce responses very close to the passive suspension system. Haider J. Abid, Jie Chen, and Ameen A. Nassar Copyright © 2015 Haider J. Abid et al. All rights reserved. Incidence and Predictors of Tuberculosis among HIV Positive Children at University of Gondar Referral Hospital, Northwest Ethiopia: A Retrospective Follow-Up Study Tue, 26 May 2015 08:31:23 +0000 Background. The aim of this study was to determine the incidence of tuberculosis and its predictors among HIV positive children. Methods. A six-year retrospective follow-up study was conducted among HIV infected children aged less than 15 years. Life table was used to estimate the cumulative probability of tuberculosis free survival. Cox proportional hazards model was used to identify predictors of tuberculosis. Results. A total of 271 HIV positive children were followed for six years and produced 1100.50 person-years of observation. During the follow-up period 52 new TB cases occurred. The overall incidence density of TB was 4.9 per 100 PY. Inappropriate vaccination [AHR: 8.03 (95% CI; 4.61–13.97)], ambulatory functional status [AHR: 1.99 (95% CI; 1.04–3.81)], and having baseline anemia [AHR: 2.23 (95% CI; 1.19–4.15)] were important predictors of time to TB occurrence. Conclusion. TB incidence rate was high. Early diagnosis and treatment of anemia and strengthening immunization program would reduce the risk of TB occurrence. Sualiha Gebeyaw Ayalaw, Kefyalew Addis Alene, and Akilew Awoke Adane Copyright © 2015 Sualiha Gebeyaw Ayalaw et al. All rights reserved. Effect of In Vitro Testing Parameters on Ceftazidime-Avibactam Minimum Inhibitory Concentrations Tue, 19 May 2015 11:23:33 +0000 Effects of varying in vitro susceptibility testing parameters of the broth microdilution assay on ceftazidime-avibactam MICs were determined and compared to meropenem and piperacillin-tazobactam for 9 Enterobacteriaceae and 4 Pseudomonas aeruginosa isolates. The effect of varying incubation conditions (ambient air or 5% CO2), pH of medium, medium composition (cation-adjusted Mueller Hinton Broth with and without laked horse blood and Haemophilus Test Medium), cation content of the medium, and inoculum density were tested. Most variations had no effect on ceftazidime-avibactam MIC values (no more than a 2-fold change). However, acidic pH or high inoculum resulted in 4- to 16-fold changes in MIC, which was similar to those observed for meropenem and piperacillin-tazobactam under these conditions. Overall, this study shows that slight variations in testing parameters during routine MIC testing will likely have no significant effect on ceftazidime-avibactam MIC values. Tiffany R. Keepers, Marcela Gomez, Donald Biek, Ian Critchley, and Kevin M. Krause Copyright © 2015 Tiffany R. Keepers et al. All rights reserved. Experience with Clinically Diagnosed Down Syndrome Children Admitted with Diarrhea in an Urban Hospital in Bangladesh Thu, 07 May 2015 09:54:46 +0000 There is lack of information in the medical literature on clinically diagnosed Down syndrome children presenting with diarrhea. Our aim was to describe our experience with Down syndrome patients admitted with diarrhea by evaluating the factors associated with Down syndrome presenting with diarrheal illness. In this retrospective chart analysis, we enrolled all the diarrheal children aged 0–59 months admitted to the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr, b), from March 2011 to February 2013. Down syndrome children with diarrhea constituted cases and randomly selected threefold diarrheal children without Down syndrome constituted controls. Among 8422 enrolled children 32 and 96 were the cases and the controls, respectively. Median age (months) of the cases and the controls was comparable (7.6 (4.0, 15.0) versus 9.0 (5.0, 16.8); ). The cases more often presented with severe acute malnutrition, developmental delay, congenital heart disease, hypothyroidism, sepsis, hypocalcemia, developed hospital acquired infection (HAI) during hospitalization, and required prolonged stay at hospital compared to the controls (for all ). Thus, diarrheal children with clinically diagnosed Down syndrome should be investigated for these simple clinical parameters for their prompt management that may prevent HAI and prolonged hospital stay. Rina Das, Anupam Sarker, Haimanti Saha, Abu Sadat Mohammad Sayeem Bin Shahid, K. M. Shahunja, and Mohammod Jobayer Chisti Copyright © 2015 Rina Das et al. All rights reserved. Development of Simultaneous Derivative Spectrophotometric and HPLC Methods for Determination of 17-Beta-Estradiol and Drospirenone in Combined Dosage Form Mon, 27 Apr 2015 07:45:55 +0000 Simple, rapid spectrophotometric, and reverse-phase high performance liquid chromatographic methods were developed for the concurrent analysis of 17-beta-estradiol (ESR) and drospirenone (DRS). The spectrophotometric method was based on the determination of first derivative spectra and determined ESR and DRS using the zero-crossing technique at 208 and 282 nm, respectively, in methanol. The linear range was 0.5–32.0 µg·mL−1 for DRS and 0.5–8.0 µg·mL−1 for EST. The limit of detection (LOD) values were 0.14 µg·mL−1 and 0.10 µg·mL−1 and limit of quantification (LOQ) values were 0.42 µg·mL−1 and 0.29 µg·mL−1 for ESR and DRS, respectively. The chromatographic method was based on the separation of both analytes on a C18 column with a mobile phase containing acetonitrile and water (70 : 30, v/v). Detection was performed with a UV-photodiode array detector at 279 nm. The linear range was 0.08–2.5 µg·mL−1 for DRS and 0.23–7.5 µg·mL−1 for EST. LOD values were 0.05 µg·mL−1 and 0.02 µg·mL−1 and LOQ values were 0.15 µg·mL−1 and 0.05 µg·mL−1 for ESR and DRS, respectively. These recommended methods have been applied for the simultaneous determination of ESR and DRS in their tablets. Zeynep Aydoğmuş, Ece Merve Yılmaz, Sevgi Yörüsün, and Samet Akpınar Copyright © 2015 Zeynep Aydoğmuş et al. All rights reserved. Relationship between Liver Mitochondrial Respiration and Proton Leak in Low and High RFI Steers from Two Lineages of RFI Angus Bulls Thu, 23 Apr 2015 08:39:57 +0000 The objective of this research is to evaluate liver mitochondrial oxygen consumption and proton leak kinetics in progeny from two lineages of Angus bulls with high and low residual feed intake (RFI). Two Angus bulls were selected based on results from a genetic test for RFI and were used as sires. Eight offspring at 10-11 months of age from each sire were housed in individual pens for 70–105 days following a diet adaptation period of 14 days. Progeny of the low RFI sire had 0.57 kg/d () lower average RFI than progeny of the high RFI sire. There was no difference in dry matter intake between low and high RFI steers, but low RFI steers gained more body weight () and tended to have higher average daily gains (). State 3 and State 4 respiration, RCR, and proton leak did not differ between high and low RFI steers (, , , and , resp.). Therefore, the increase in bodyweight gain which distinguished the low RFI steers from the high RFI steers may be associated with other metabolic mechanisms that are not associated with liver mitochondrial respiration and proton leak kinetics. G. Acetoze, K. L. Weber, J. J. Ramsey, and H. A. Rossow Copyright © 2015 G. Acetoze et al. All rights reserved. Electronically Tunable Differential Integrator: Linear Voltage Controlled Quadrature Oscillator Sun, 19 Apr 2015 08:14:53 +0000 A new electronically tunable differential integrator (ETDI) and its extension to voltage controlled quadrature oscillator (VCQO) design with linear tuning law are proposed; the active building block is a composite current feedback amplifier with recent multiplication mode current conveyor (MMCC) element. Recently utilization of two different kinds of active devices to form a composite building block is being considered since it yields a superior functional element suitable for improved quality circuit design. The integrator time constant and the oscillation frequency are tunable by the control voltage of the MMCC block. Analysis indicates negligible phase error for the integrator and low active -sensitivity relative to the device parasitic capacitances. Satisfactory experimental verifications on electronic tunability of some wave shaping applications by the integrator and a double-integrator feedback loop (DIFL) based sinusoid oscillator with linear variation range of 60 KHz~1.8 MHz at low THD of 2.1% are verified by both simulation and hardware tests. Rabindranath Nandi, Sandhya Pattanayak, Palaniandavar Venkateswaran, and Sagarika Das Copyright © 2015 Rabindranath Nandi et al. All rights reserved. Retracted: Detection of Abnormal Hemoglobin Variants by HPLC Method: Common Problems with Suggested Solutions Thu, 16 Apr 2015 13:04:37 +0000 International Scholarly Research Notices Copyright © 2015 International Scholarly Research Notices. All rights reserved. Examining Provincial HPV Vaccination Schemes in Canada: Should We Standardise the Grade of Vaccination or the Number of Doses? Sun, 12 Apr 2015 07:41:27 +0000 Human papillomavirus (HPV) infection is the most common sexually transmitted infection, which is linked to several cancers and genital warts. Depending on the Canadian province, the quadrivalent vaccine is given to girls in grades 4 through 10 with either a two- or three-dose schedule. We use a mathematical model to address the following research questions: (1) Does the grade at which the girls are vaccinated significantly affect the outcome of the program? (2) What coverage rate must the provinces reach in order to reduce the impact of HPV on the Canadian population? (3) What are the implications of vaccinating with two versus three doses? The model suggests the grade of vaccination and the number of doses do not make a significant difference to the outcome of the public vaccination program. The most significant factor is the coverage rate of children and adults. We recommend that provinces vaccinate as early as possible to avoid vaccine failure due to previous infection. We also recommend that the main focus of the program should be on obtaining a large enough coverage rate for children and/or adults in order to achieve the desired outcome with either two or three doses of the vaccine. Carley Rogers and Robert J. Smith? Copyright © 2015 Carley Rogers and Robert J. Smith?. All rights reserved. Antiretroviral Treatment Adherence Rate and Associated Factors among People Living with HIV in Dubti Hospital, Afar Regional State, East Ethiopia Thu, 09 Apr 2015 08:57:28 +0000 Introduction. Antiretroviral Therapy has transformed HIV infection into a chronic manageable disease; it requires near perfect adherence rates (as high as 95%). In this study, we assessed antiretroviral treatment adherence rate and associated factors among people living with HIV in Dubti Hospital. Methods. A retrospective cross-sectional study design was conducted within February 1–30, 2014. All HIV-infected patients above the age of 18 years who took first line Antiretroviral Therapy were eligible for inclusion of the study. Adherence Scale was used for labeling patients as adherent or nonadherent. All HIV-infected patients record data were collected from the medical records, entered, and analyzed using Epi Info 7 and SPSS Version 20. Multivariable analysis was used to identify the relative effect of explanatory variables on low adherence rate. Results. A total of 370 patients aged 18 years and above, who started ART, were included in this study. The self-reported adherence rate of the patient on ART was 81.1%. Independent predictors of adherence were treatment duration. Conclusion. Adherence rate was associated with time to ART. That is, the longer they were on ART, the lesser they adhered. Bekele Belayihun and Rahma Negus Copyright © 2015 Bekele Belayihun and Rahma Negus. All rights reserved. Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats Sun, 05 Apr 2015 15:58:34 +0000 Rats neonatally treated with monosodium L-glutamate (MSG) are deeply dysfunctional in adulthood. We explored the effect of an oral low dose of metformin treatment in male MSG rats on adipoinsular axis and visceral adipose tissue (VAT) dysfunctions, in both basal (nonfasting) and endotoxemia conditions. MSG rats, treated or not treated with metformin (30 days prior to experimentation), and control litter-mates (CTR) were studied at 90 days of age. Peripheral concentrations of glucose, lipids, and hormones were determined in basal and post-lipopolysaccharide (LPS) treatment conditions. Food intake and body weight (BW) were recorded and VAT mass and leptin mRNA levels were evaluated. Data indicated that MSG rats were lighter and displayed hypercorticosteronemia, hypophagia, adipoinsular axis hyperactivity, and enhanced VAT mass associated with an increased leptin gene expression. Interestingly, metformin-treated MSG rats corrected BW catch-up and counteracted VAT (mass and leptin mRNA level) and adipoinsular axis (basal and post-LPS) dysfunctions. Thus metformin treatment in MSG rats is able to correct several VAT and metabolic-endocrine dysfunctions. Our study suggests that a low-dose metformintherapy is effective to correct, at least in part, adipoinsular axis dysfunction in hypertrophic obese phenotypes, such as that of the human Cushing syndrome. Daniel Castrogiovanni, Luisina Ongaro, Guillermina Zuburía, Andrés Giovambattista, and Eduardo Spinedi Copyright © 2015 Daniel Castrogiovanni et al. All rights reserved. Enhancing Fluoride Mediated Dentine Sensitivity Relief through Functionalised Tricalcium Phosphate Activity Thu, 02 Apr 2015 14:32:48 +0000 Background. To assess the clinical efficacy of a dentifrice containing fluoride and functionalised tricalcium phosphate (fTCP) in reducing dentine sensitivity. Methods. A 10-week parallel blind randomised control trial was conducted. Subjects were assigned to one of four groups and instructed to brush twice daily: A: Colgate Cavity Protection (1000 ppmF-MFP); B: Sensodyne Total Care (1000 ppmF-NaF + 19300 ppmK+-KNO3); C: Clinpro Tooth Crème (950 ppmF-NaF + fTCP); and D: Clinpro Tooth Crème (brushing + additional topical application). Seventy-one patients were assessed at baseline, 6 weeks, and 10 weeks for cold, tactile, and hypertonic sensitivity using the NRS-11 pain rating scale. A combined modalities sensitivity score (CMS) was calculated. Results. At 6 weeks, patients reported the following reduction in CMS: A (20%); B (30%); C (42%); D (52%). At 10 weeks, patients reported the following reduction in CMS: A (18%), B (40%), C (24%), and D (54%). The only CMS comparisons to show a significant difference () were between Groups A and D (6 and 10 weeks). Conclusions. Addition of fTCP to a dentifrice enhances the ability of dentifrice fluoride in reducing dentine sensitivity. Using Clinpro Tooth Crème twice daily for brushing can be as effective to reduce dentine sensitivity as twice daily brushing using Sensodyne Total Care. However, additional nightly topical application of fTCP, in addition to twice daily brushing, showed an enhanced reduction in dentine sensitivity. Steven J. Naoum, Andrea Lenard, F. Elizabeth Martin, and Ayman Ellakwa Copyright © 2015 Steven J. Naoum et al. All rights reserved. Depression, Alcohol Abuse, and Alcoholism in One versus Two Parents and the Implications for Child Attachment and Self-Regulation in Infancy through Adolescence Sun, 29 Mar 2015 08:21:44 +0000 This study’s purpose was to determine whether the influence of combined parental disorders can cause greater frequency in the occurrence of insecure child attachment and dysfunctions in self-regulation as opposed to the influence of one parent having a disorder. The research design is a quantitative meta-analysis that combined effects from 10 studies to establish differences in the frequency of occurrence for insecure child attachment and dysfunctions in self-regulation through an examination of Cohen’s d. Global analysis of Cohen’s effect (d) indicated that children being reared by two disordered parents had higher frequency in occurrence of insecure attachment and self-regulation dysfunction than those children reared by only one disordered parent. By addressing the issues surrounding the child population where both parents are disordered, children would have a better chance at healthy development by way of interventions that minimize the occurrence of child psychopathology and foster improvements in the social and overall human condition. Brenda Ridgeway Copyright © 2015 Brenda Ridgeway. All rights reserved. Retracted: Nontraumatic Lesions of the Clavicle in a Paediatric Population: Incidence and Management Wed, 25 Mar 2015 09:11:33 +0000 International Scholarly Research Notices Copyright © 2015 International Scholarly Research Notices. All rights reserved. Simulation-Based Rule Generation Considering Readability Tue, 24 Mar 2015 10:14:29 +0000 Rule generation method is proposed for an aircraft control problem in an airport. Designing appropriate rules for motion coordination of taxiing aircraft in the airport is important, which is conducted by ground control. However, previous studies did not consider readability of rules, which is important because it should be operated and maintained by humans. Therefore, in this study, using the indicator of readability, we propose a method of rule generation based on parallel algorithm discovery and orchestration (PADO). By applying our proposed method to the aircraft control problem, the proposed algorithm can generate more readable and more robust rules and is found to be superior to previous methods. H. Yahagi, S. Shimizu, T. Ogata, T. Hara, and J. Ota Copyright © 2015 H. Yahagi et al. All rights reserved. The Asymptotics of Recovery Probability in the Dual Renewal Risk Model with Constant Interest and Debit Force Sun, 22 Mar 2015 13:44:41 +0000 The asymptotic behavior of the recovery probability for the dual renewal risk model with constant interest and debit force is studied. By means the idea of Markov Skeleton method, we studied the times that the random premium incomes happened and transformed the continuous time model into a discrete time model. By investigating the fluctuations of this discrete time model, we obtained the asymptotic behavior when the random premium income belongs to a kind of heavy-tailed distributions. Hao Wang and Lin Xu Copyright © 2015 Hao Wang and Lin Xu. All rights reserved.