Research Article

Body Mass and Fat Mass in Refractory Asthma: An Observational 1 Year Follow-Up Study

Table 2

Characteristics according to weight change grouping in women.

Weight loss group No weight change group Weight gain group Value
Baseline1 yearDelta ΔBaseline1 yearDelta ΔBaseline1 yeardelta Δ

Weight, (kg)81 (4)76 (5)−4 (−17 to 9)74 (4)74 (4)0 (−12 to 12)77 (3)81 (3)4 (−5 to 14)<0.001
BMI (kg/m2)31 (2)29 (2)−2 (−6 to 3)30 (2)30 (2)0 (−5 to 5)30 (1)32 (1)2 (−2 to 5)<0.001
FEV1 % predicted#78 (4)84 (4)6 (−6 to 18)77 (6)78 (7)1 (−19 to 20)83 (4)81 (4)−3 (−14 to 8)0.51
FENO (ppb)24.8 (12.9 to 47.7)25.0 (17.0 to 36.9)1.0 (0.5 to 2.0)44.5 (22.9 to 86.6)34.9 (19.7 to 61.9)1.2 (0.6 to 2.9)31.8 (21.6 to 46.8)23.4 (17.0 to 32.3)−1.4 (−2.2 to 0.8)0.76
Exacerbation rate4.5 (0.9)3.9 (0.8)−0.6 (−3.0 to 1.8)3.7 (0.4)2.3 (0.6)−1.4 (−2.9 to 0)3.7 (0.6)2.7 (0.5)−1.1 (−2.6 to 0.5)0.49
Maintenance prednisolone, %4742676756590.11
Prednisolone dose, mg*11 (5–40)9 (3–20)−2.6 (−11 to 6)10 (5–20)9 (5–20)−1 (−6 to 4)9 (5–35)7 (3–25)−1 (−5 to 3)0.96
Inhaled corticosteroid dose (ug)1874 (257)1889 (111)15 (−566 to 596)1325 (121)1538 (117)213 (−130 to 555)1371 (105)1439 (105)68 (−229 to 365)0.62
JACQ score2.6 (0.3)2.4 (0.3)−0.2 (−1.0 to 0.6)2.5 (0.3)2.3 (0.2)−0.2 (−0.9 to 0.6)2.3 (0.2)2.2 (0.2)−0.1 (−0.8 to 0.5)0.96
JACQ score(independent of )2.5 (0.3)2.4 (0.3)−0.1 (−1.1 to 0.8)2.3 (0.3)2.2 (0.2)−0.1 (−0.9 to 0.6)2.3 (0.3)2.1 (0.2)−0.1 (−0.8 to 0.6)0.92
Sputum neutrophils (%)44 (6)65 (5)20 (4 to 36)74 (6)76 (4)2 (−14 to 18)51 (4)69 (5)18 (4 to 32)0.06
Sputum eosinophils (%)6.5 (2.4 to 17.4)2.9 (1.2 to 7.0)−2.2 (−7.9 to 0.9)3.4 (1.4 to 8.4)4.6 (1.4 to 14.9)0.7 (−2.9 to 0.2)6.0 (3.2 to 11.2)2.6 (1.2 to 5.8)−2.3 (−6.1 to 0.9)0.01

BMI: body mass index; FEV1: forced expiratory volume in 1 second; FENO: fraction exhaled nitric oxide, JACQ: juniper asthma control questionnaire score; data presented as mean (SEM) unless otherwise stated. #postbronchodilator; geometric mean [95% CI];mean (95% CI); mean [range]; BDP equivalent; ~median (IQR); mean difference (95% confidence interval); and fold change (95% confidence interval).