Review Article

The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology

Table 4

Mediators secreted and immunomodulatory proteins expressed by human ASM cells.

FactorsReferences

Cell adhesion/costimulatory molecules, receptors
CD11a[117]
CD40 (TNFRSF5), CD40L (TNFSF5), CD44[118]
CD80, CD86[117]
OX40L (TNFSF4)[119]
Adhesion molecules: ICAM-1, VCAM-1[118]
Major histocompatibility complex (MHC) II[120]
Toll-like receptors: TLR2, 3, 4[121]
Chemokine receptors: CCR3, 7[122]
Chemokine receptors: CXCR1, 3, 4[122]
Receptors for IL-4, 6, 12, 13, 17, 22 and IFN-γ[116, 123]
Chemokines, cytokines, and growth factors
CCL2, 5, 7, 8, 11, 17, 19[124128]
CXCL8, 10[129, 130]
CX3CL1[55]
IL-2, 5, 6, 11, 12[57, 131]
Interferon- (IFN-) γ[57]
Connective tissue growth factor (CTGF)[132]
Granulocyte macrophage-colony stimulating factor (GM-CSF)[133]
Stem cell factor (SCF)[134]
Transforming growth factor- (TGF-) β1[135]
Vascular endothelial growth factor (VEGF)[136]
ECM proteins
Chondroitin sulfate[137]
Collagens I, III, IV, V[137]
Decorin, elastin, fibronectin, laminin, perlecan[137]
Thrombospondin[137]
Tissue inhibitor of MMPs- (TIMPs-) 1, 2[138]
Enzymes
Matrix-metalloproteinases- (MMPs-) 9, 12[139]