Review Article

The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology

Table 6

Promigratory factors for human ASM cells.

FactorsReferences

Growth factors/cytokines/chemokines
FGF2, PDGF, TGF-α (TNFSF2), TGF-β[229, 230]
IL-1β, IL-17A, IL-17F, IL-22[123, 230]
CCL5, 11, 19[128, 231, 232]
CXCL8[231]
Leukotriene E4[233]
ECM components
Collagens I, III, V[233]
Fibronectin, laminin[233]
Enzymes
Matrix metalloproteinase- (MMP-)3[234]
Others
Thrombin[235]
Urokinase plaminogen activator[236]