Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice
Figure 2
Inhalation of OPA vapor induces the expression of Th2 and pro/anti-inflammatory cytokines in the draining lymph nodes of mice. Mice were exposed to OPA (125, 250, 500, 1000 ppb) or filtered air according to the schedule shown in Figure 1. Two days following the final exposure, the mandibular lymph nodes from the left side of the neck were removed and processed for gene expression analysis. Data are presented as mean () and represent fold change relative to the concurrent control group. *Indicates that the cytokine was significantly increased at one or more of the OPA concentrations. Refer to Table S1 of the supplementary material available online at doi: 10.1155/2011/751052 for the empirical gene expression data.
