Haptenation: Chemical Reactivity and Protein Binding

Table 1

Common mechanistic domains.

Mechanistic domain
Michael acceptors	Acylating agents	Schiff base formers	SNAr electrophiles	SN1/SN2 electrophile
X = electron withdrawing	X = electron withdrawing and a good leaving group.	Attacking nucleophile is an amine (NH2-)	X = usually a halogen or pseudohalogen.; Y1,Y2 = electron withdrawing	X = usually electron withdrawing and a good leaving group.