Table 2: Innate lymphoid cells (ILCs) familya,b.

Cell typeDate of discovery
and naming in the first publish
Anatomical
locations
Major stimulating
and development-effective
cytokines
Major transcription
factors and molecules
needed for development
Major cytokines
produced by cells
Major
surface
markers
Major functions
and pathology
Reference

NK cells
(cytotoxic ILCs)
(i) Kiessling et al. 1975
[29]
(ii) Herberman et al. 1975
[30]
(i) Secondary lymphoid tissues
(ii) Blood
(iii) Mucosal tissues
(iv) BM and thymus (less common)
(i) IL-12, IL-15, IL-18
(ii) IL-2, IL-21
Id2
Tox
T-bet
E4BP4
Eomes
IFN-   
IL-3
IL-10
TNF-α
G-CSF
GM-CSF
CCL2
CCL3
CCL4
CCL5
XCL-1
IL-8
(i) Cytokine receptors1  
(ii) Chemokine receptors2  
(iii) Adhesion molecules3  
(iv) Activating receptors4  
(v) Inhibitory receptors5
(i) Innate responses against viral infections
(ii) Immune surveillance against tumors
[2935]

Rorγt+ ILCsFirst subset: Mebius et al. 1997 [36](i) Fetal lymphoid organs
(ii) Tonsils, intestines, spleen, Peyer’ patches
(i) IL-1β, IL-23
(ii) IL-7
Ror t
Id2
Tox
AhR
Notch2 (just in adults)
IL-17
IL-22
IL-2
IL-13
GM-CSF
TNF-α
LT
CXCL-18
(i) In all subsets: CD127 (IL-7Rα), CD161, CD117 (c-kit), OX40L, CD30L
(ii) In some subsets: CD4, CD90, CD56, NKP44 ( in human), NKP46 (in mouse), RANK, RANKL
(i) Lymphoid tissue formation (organogenesis)
(ii) Tissue repair
(iii) Innate immunity against bacterial and yeast infections
(iv) Triggering of IgA production independently from T cells
(v) Mucosal immunity6  
(vi) Mucosal homeostasis7  
(vii) Intestine and cancer pathology8
[2, 3639]

Type 2 ILCs (ILCs2)2001, 2002,
2010, 2011
(more detail in Table 3)
(i) FALC
(ii) Lungs and gut
(iii) mLN
(iv) Palatine tonsils
(v) Spleen
(vi) Liver
(viii) Peripheral blood
(i) IL-25, IL-33
(ii) IL-7
Id2
IL-5
IL-13
(i) In human: CRTH2 (GPR44), IL-7R , IL-7RB, CD25, ST2
(ii) In mouse: CD44, Thy1, c-kit
(i) Helminth expulsion
(ii) Tissue homeostasis
(iii) Airway inflammation and remodeling
[2]

aThe biology and functions of NK cells and Rorγt+ ILCs are in more details than ILC 2. The latter cells are our target cells in this paper so we meet them in great details through the text. bEach three major cell types of ILC family are actually a heterogeneous population so in this table just common features of subsets of each subfamily have been indicated.
1IL-1R, IL-2R, IL-12R, IL-15R, IL-18R, IFN-α. 2CCR2, CCR5, CCR7, CXCR1, CXCR3, CXCR4, CXCR6,CX3CR1, S1P5, Chem23R. 3CD2, CD56, CD122, DX5, CD11b, DNA M1, β1-integrins, β2-integrins. 4NKPs (NCRs), CD16, NKG2D, NKR-P1C, KIR-S, CD94/NKG2C, CRACC, ly9, CD84, NTB4, 2B4. 5LAIR1, KLRG1, NKR-P1B, NKR-P1D, TIGIT, CEACAM1, KIR-L, LILRB1, ly49, CD94/NKG2A.
6For example, by interaction with T cell, through CD30L and OX40L, that causes survival of Th2 and memory T cells. 7For example, by TNF-α-dependent activation of matrix metalloproteinases that lead to TGF-β production and in return IgA secretion by B cells. 8In intestine pathology, for example, by by IL-17 production and in return promotion and aggravation of mucosal inflammation. In cancer pathology, for example, by tumor expansion through recalling and recruitment immune suppressive cells.
Ror t: transcription factor retinoic acid (RA) receptor-related orphan receptor (Ror) t, Tox: thymocyte selection-associated high-mobility group box protein, Eomes: eomesodermin, T-bet (Tbx21): T-box transcription factor expressed in T cells, E4BP4 (NFIL3): nuclear factor IL-3 regulated (a basic leucine zipper transcription factor), AhR: aryl hydrocarbon receptor, LT: lymphotoxin, FALC: fat-associated lymphoid cluster, mLN: mesenteric lymph nodes, BM: bone marrow.