Sphingolipids: A Potential Molecular Approach to Treat Allergic Inflammation
Figure 1
Histamine receptors on ECs. Two histamine receptors (H1 and H2) are found on ECs. Within minutes of histamine binding to its receptors, the G-protein subunits are activated to initiate intracellular signalling. The αq subunit of the G-protein contributes to reduced cAMP accumulation, induced ERK1/2, and induced inositol phospholipid (PI3K) signalling. The β and γ subunits contribute to the activation of NFκB and subsequent translocation into the nucleus where transcriptional processes are regulated causing cellular changes, such as vascular contraction and permeability, all of which are important for immune regulation and inflammation.
