The Heterogeneity of Asthma Phenotypes in Children and Young Adults

Table 3

IL-4 receptor polymorphisms and asthma phenotypes.

IL-4 receptor marker	NA^1𝑛 (%)	EOA^2𝑛 (%)	LOA^3𝑛 (%)
rs2057768
AA	14 (7.2)	0 (0.0)	5 (33.3)
AG	74 (38.3)	2 (40.0)	5 (33.3)
GG	105 (54.5)	3 (60.0)	5 (33.3)
𝑃 value^4		1.0	0.006
𝑃 value^5	0.018
rs2107356
AA	38 (18.4)	1 (20.0)	1 (6.3)
AG	115 (55.6)	4 (80.0)	6 (37.5)
GG	54 (26.0)	0 (0.0)	9 (56.2)
𝑃 value^4		0.001	0.414
𝑃 value^5	<0.001
rs3024632
CC	0 (0.0)	0 (0.0)	0 (0.0)
CT	23 (11.2)	1 (20.0)	1 (6.7)
TT	182 (88.8)	4 (80.0)	14 (93.3)
𝑃 value^4		1.000	0.711
𝑃 value^5	0.897
rs1805010
AA	85 (38.1)	2 (33.3)	3 (18.7)
AG	117 (52.5)	4 (66.7)	6 (37.5)
GG	21 (9.4)	0 (0.0)	7 (43.8)
𝑃 value^4		0.715	0.001
𝑃 value^5	0.003
rs1805015
AA	157 (70.8)	3 (50.0)	16 (94.1)
AG	56 (25.2)	3 (50.0)	1 (5.9)
GG	9 (4.0)	0 (0.0)	0 (0.0)
𝑃 value^4		0.487	0.093
𝑃 value^5	0.138
rs1801275
CC	11 (4.9)	0 (0.0)	0 (0.0)
CT	78 (35.1)	3 (50.0)	5 (27.8)
TT	133 (60.0)	3 (50.0)	13 (72.2)
𝑃 value^4		0.756	0.461
𝑃 value^5	0.688

¹No asthma, ²early onset asthma, ³late onset asthma.
⁴As compared to no asthma, 𝑃 value based on Monte Carlo Tests with 100000 iterations for 3×2 tables, and Exact Tests for 2×2 tables.
⁵Between all groups, 𝑃 value based on Monte Carlo Test, with 100000 iterations.