The Heterogeneity of Asthma Phenotypes in Children and Young Adults : Table 3

Table 3: IL-4 receptor polymorphisms and asthma phenotypes.


IL-4 receptor marker	NA¹ (%)	EOA² (%)	LOA³ (%)

rs2057768
AA	14 (7.2)	0 (0.0)	5 (33.3)
AG	74 (38.3)	2 (40.0)	5 (33.3)
GG	105 (54.5)	3 (60.0)	5 (33.3)
value⁴		1.0	0.006
value⁵	0.018

rs2107356
AA	38 (18.4)	1 (20.0)	1 (6.3)
AG	115 (55.6)	4 (80.0)	6 (37.5)
GG	54 (26.0)	0 (0.0)	9 (56.2)
value⁴		0.001	0.414
value⁵	<0.001

rs3024632
CC	0 (0.0)	0 (0.0)	0 (0.0)
CT	23 (11.2)	1 (20.0)	1 (6.7)
TT	182 (88.8)	4 (80.0)	14 (93.3)
value⁴		1.000	0.711
value⁵	0.897

rs1805010
AA	85 (38.1)	2 (33.3)	3 (18.7)
AG	117 (52.5)	4 (66.7)	6 (37.5)
GG	21 (9.4)	0 (0.0)	7 (43.8)
value⁴		0.715	0.001
value⁵	0.003

rs1805015
AA	157 (70.8)	3 (50.0)	16 (94.1)
AG	56 (25.2)	3 (50.0)	1 (5.9)
GG	9 (4.0)	0 (0.0)	0 (0.0)
value⁴		0.487	0.093
value⁵	0.138

rs1801275
CC	11 (4.9)	0 (0.0)	0 (0.0)
CT	78 (35.1)	3 (50.0)	5 (27.8)
TT	133 (60.0)	3 (50.0)	13 (72.2)
value⁴		0.756	0.461
value⁵	0.688

¹No asthma, ²early onset asthma, ³late onset asthma.
⁴As compared to no asthma, value based on Monte Carlo Tests with 100000 iterations for tables, and Exact Tests for tables.
⁵Between all groups, value based on Monte Carlo Test, with 100000 iterations.