Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life

Figure 1

An illustration depicting the types of immune cells involved in a Th2-mediated allergic response. Antigen presenting cells (macrophages or DCs) take up the antigen, process it, and present it on the MHC molecule on the cell surface. The antigen presenting cells induce naïve T cells towards Th1 or Th2. Th2 response is mainly responsible for downstream events that include activation of B cells, production of IgE, and binding of IgE to Fcε receptor on the cell surface of mast cells, resulting into mast cell degranulation and inflammation.