Table 1: DC subsets in patients with asthma.

Clinical Condition Altered DC phenotypes References Asthma pDC (HLA-DR+, CD123+) increased in BALF mDC (HLA-DR+, CD11c+) increased in BALF [99] Allergic asthma mDC (BDCA-3+, mannose receptor+) increased in BALF [100] Allergic asthma pDC (BDCA4+) with increased FcεRI in blood mDC (CD1c+) with increased FcεRI in blood [101, 102] Asthma Increased DC proportions in peripheral blood [103] Allergic asthma patients challenged with allergen Increased pDC and mDC in sputum [104] Asthma Increase in pDC1 and pDC2 expressing FcεRI [105] Repeated exposure to allergen Depletion of mDCs [23] Asthmatic children DC2 (CD11c−, CD123high+) decreased in blood [106] Asthmatic patients Increased CD1a+ cells in bronchial mucosa [107] Experimentally elicited allergic rhinitis pDC increased in nasal mucosa [108] Asthma pDC increased; decreased mDC : pDC ratio in blood [109] Children with asthma Deficiency of circulating pDC [110] Atopic patients with chronic rhinosinusitis Increased FcεRI on DC (CD1+) [111]

Abbreviations: BALF: bronchoalveolar lavage fluid, mDC: myeloid DC, pDC: plasmacytoid DC, BDCA: blood dendritic cell antigen.