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Journal of Allergy
Volume 2012 (2012), Article ID 236075, 9 pages
http://dx.doi.org/10.1155/2012/236075
Review Article

The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation

1Committee on Molecular Pathology and Molecular Medicine, University of Chicago, Chicago, IL 60637, USA
2Interdisciplinary Scientist Training Program and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
3Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA

Received 11 June 2012; Accepted 18 September 2012

Academic Editor: Hamida Hammad

Copyright © 2012 Jesse W. Williams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses.