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Journal of Allergy
Volume 2012 (2012), Article ID 236075, 9 pages
The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
1Committee on Molecular Pathology and Molecular Medicine, University of Chicago, Chicago, IL 60637, USA
2Interdisciplinary Scientist Training Program and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
3Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Received 11 June 2012; Accepted 18 September 2012
Academic Editor: Hamida Hammad
Copyright © 2012 Jesse W. Williams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. G. Johansson and J. Lundahl, “Asthma, atopy, and IgE: what is the link?” Current Allergy and Asthma Reports, vol. 1, no. 2, pp. 89–90, 2001.
- S. T. Holgate, “Innate and adaptive immune responses in asthma,” Nature Medicine, vol. 18, pp. 673–683, 2012.
- N. R. Bhakta and P. G. Woodruff, “Human asthma phenotypes: from the clinic, to cytokines, and back again,” Immunological Reviews, vol. 242, no. 1, pp. 220–232, 2011.
- K. D. Stone, C. Prussin, and D. D. Metcalfe, “IgE, mast cells, basophils, and eosinophils,” Journal of Allergy and Clinical Immunology, vol. 125, no. 2, pp. S73–S80, 2010.
- H. C. Oettgen, T. R. Martin, A. Wynshaw-Boris, C. Deng, J. M. Drazen, and P. Leder, “Active anaphylaxis in IgE-deficient mice,” Nature, vol. 370, no. 6488, pp. 367–370, 1994.
- P. D. Mehlhop, M. Van De Rijn, A. B. Goldberg et al., “Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 4, pp. 1344–1349, 1997.
- R. C. Aalberse, “Specific IgE and IgG responses in atopic versus nonatopic subjects,” American Journal of Respiratory and Critical Care Medicine, vol. 162, no. 3, pp. S124–S127, 2000.
- H. J. Gould and B. J. Sutton, “IgE in allergy and asthma today,” Nature Reviews Immunology, vol. 8, no. 3, pp. 205–217, 2008.
- Q. Hamid and M. Tulic, “Immunobiology of asthma,” Annual Review of Physiology, vol. 71, pp. 489–507, 2009.
- J. R. Stokes and T. B. Casale, “Allergic rhinitis and asthma: celebrating 100 years of immunotherapy,” Current Opinion in Immunology, vol. 23, pp. 808–813, 2011.
- F. Nimmerjahn and J. V. Ravetch, “Anti-inflammatory actions of intravenous immunoglobulin,” Annual Review of Immunology, vol. 26, pp. 513–533, 2008.
- P. Bruhns, “Properties of mouse and human IgG receptors and their contribution to disease models,” Blood, vol. 119, no. 24, pp. 5640–5649, 2012.
- F. Nimmerjahn and J. V. Ravetch, “Fc-receptors as regulators of immunity,” Advances in Immunology, vol. 96, pp. 179–204, 2007.
- M. Turner, E. Schweighoffer, F. Colucci, J. P. Di Santo, and V. L. Tybulewicz, “Tyrosine kinase SYK: essential functions for immunoreceptor signalling,” Immunology Today, vol. 21, no. 3, pp. 148–154, 2000.
- G. Sarmay, G. Koncz, I. Pecht, and J. Gergely, “Fcγ receptor type lib induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell,” Immunology Letters, vol. 57, no. 1–3, pp. 159–164, 1997.
- F. Nimmerjahn and J. V. Ravetch, “Fcγ receptors as regulators of immune responses,” Nature Reviews Immunology, vol. 8, no. 1, pp. 34–47, 2008.
- P. T. Harrison, W. Davis, J. C. Norman, A. R. Hockaday, and J. M. Allen, “Binding of monomeric immunoglobulin G triggers FcγRI-mediated endocytosis,” Journal of Biological Chemistry, vol. 269, no. 39, pp. 24396–24402, 1994.
- S. M. Canfield and S. L. Morrison, “The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region,” Journal of Experimental Medicine, vol. 173, no. 6, pp. 1483–1491, 1991.
- P. T. Harrison and J. M. Allen, “High affinity IgG binding by FcγRI (CD64) is modulated by two distinct IgSF domains and the transmembrane domain of the receptor,” Protein Engineering, vol. 11, no. 3, pp. 225–232, 1998.
- W. L. W. Hazenbos, I. A. F. M. Heijnen, D. Meyer et al., “Murine IgG1 complexes trigger immune effector functions predominantly via FcγRIII (CD16),” Journal of Immunology, vol. 161, no. 6, pp. 3026–3032, 1998.
- M. D. Hulett and P. Mark Hogarth, “Molecular basis of Fc receptor function,” Advances in Immunology, vol. 57, pp. 1–127, 1994.
- D. A. Mancardi, B. Iannascoli, S. Hoos, P. England, M. Daëron, and P. Bruhns, “FcγRIV is a mouse IgE receptor that resembles macrophage FcεRI in humans and promotes IgE-induced lung inflammation,” Journal of Clinical Investigation, vol. 118, no. 11, pp. 3738–3750, 2008.
- P. Garred, T. E. Michaelsen, and A. Aase, “The IgG subclass pattern of complement activation depends on epitope density and antibody and complement concentration,” Scandinavian Journal of Immunology, vol. 30, no. 3, pp. 379–382, 1989.
- M. H. Tao, R. I. F. Smith, and S. L. Morrison, “Structural features of human immunoglobulin G that determine isotype- specific differences in complement activation,” Journal of Experimental Medicine, vol. 178, no. 2, pp. 661–667, 1993.
- D. L. Sylvestre and J. V. Ravetch, “Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade,” Science, vol. 265, no. 5175, pp. 1095–1098, 1994.
- M. Zhang, Z. Zhang, K. Garmestani et al., “Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult T-cell leukemia,” Cancer Research, vol. 64, no. 16, pp. 5825–5829, 2004.
- R. Clynes and J. V. Ravetch, “Cytotoxic antibodies trigger inflammation through Fc receptors,” Immunity, vol. 3, no. 1, pp. 21–26, 1995.
- T. Kagari, D. Tanaka, H. Doi, and T. Shimozato, “Essential role of Fcγ receptors in anti-type II collagen antibody-induced arthritis,” Journal of Immunology, vol. 170, no. 8, pp. 4318–4324, 2003.
- W. L. W. Hazenbos, J. E. Gessner, F. M. A. Hofhuis et al., “Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice,” Immunity, vol. 5, no. 2, pp. 181–188, 1996.
- Y. K. Hye, S. Kim, and H. C. Doo, “FcγRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation,” Journal of Clinical Investigation, vol. 116, no. 9, pp. 2484–2492, 2006.
- K. S. Nandakumar, M. Andrén, P. Martinsson et al., “Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB,” European Journal of Immunology, vol. 33, no. 8, pp. 2269–2277, 2003.
- T. Fujii, Y. Hamano, S. Ueda et al., “Predominant role of FcγRIII in the induction of accelerated nephrotoxic glomerulonephritis,” Kidney International, vol. 64, no. 4, pp. 1406–1416, 2003.
- N. Barnes, A. L. Gavin, P. S. Tan, P. Mottram, F. Koentgen, and P. M. Hogarth, “FcγRI-deficient mice show multiple alterations to inflammatory and immune responses,” Immunity, vol. 16, no. 3, pp. 379–389, 2002.
- A. Ioan-Facsinay, S. J. De Kimpe, S. M. M. Hellwig et al., “FcγRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection,” Immunity, vol. 16, no. 3, pp. 391–402, 2002.
- R. S. McIntosh, J. Shi, R. M. Jennings et al., “The importance of human FcgammaRI in mediating protection to malaria.,” PLoS Pathogens, vol. 3, no. 5, article e72, 2007.
- A. Giorgini, H. J. Brown, H. R. Lock et al., “FcγRIII and FcγRIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies,” Journal of Immunology, vol. 181, no. 12, pp. 8745–8752, 2008.
- L. Baudino, F. Nimmerjahn, S. A. Da Silveira et al., “Differential contribution of three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice,” Journal of Immunology, vol. 180, no. 3, pp. 1948–1953, 2008.
- Y. Kaneko, F. Nimmerjahn, M. P. Madaio, and J. V. Ravetch, “Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors,” Journal of Experimental Medicine, vol. 203, no. 3, pp. 789–797, 2006.
- Z. Jakus, T. Nemeth, J. S. Verbeek, and A. Mocsai, “Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes,” The Journal of Immunology, vol. 180, pp. 618–629, 2008.
- S. N. Syed, S. Konrad, K. Wiege et al., “Both FcγRIV and FcγRIII are essential receptors mediating type II and type III autoimmune responses via FcRγ-LAT-dependent generation of C5a,” European Journal of Immunology, vol. 39, no. 12, pp. 3343–3356, 2009.
- F. Jönsson, D. A. Mancardi, Y. Kita et al., “Mouse and human neutrophils induce anaphylaxis,” Journal of Clinical Investigation, vol. 121, no. 4, pp. 1484–1496, 2011.
- T. Takai, M. Ono, M. Hikida, H. Ohmori, and J. V. Ravetch, “Augmented humoral and anaphylactic responses in FcγRII-deficient mice,” Nature, vol. 379, no. 6563, pp. 346–349, 1996.
- K. G. Smith and M. R. Clatworthy, “FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications,” Nature Reviews Immunology, vol. 10, pp. 328–343, 2010.
- N. Dharajiya, S. V. Vaidya, H. Murai et al., “FcγRIIb inhibits allergic lung inflammation in a murine model of allergic asthma,” PLoS ONE, vol. 5, no. 2, article e9337, 2010.
- Y. Ishikawa, K. Kobayashi, M. Yamamoto et al., “Antigen-specific IgG ameliorates allergic airway inflammation via fcgamma receptor IIB on dendritic cells,” Respiratory Research, vol. 12, article 42, 2011.
- P. M. Hogarth and G. A. Pietersz, “Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond,” Nature Reviews Drug Discovery, vol. 11, pp. 311–331, 2012.
- A. Oshiba, E. Hamelmann, K. Takeda et al., “Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice,” Journal of Clinical Investigation, vol. 97, no. 6, pp. 1398–1408, 1996.
- I. Miyajima, D. Dombrowicz, T. R. Martin, J. V. Ravetch, J. P. Kinet, and S. J. Galli, “Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII: assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis,” Journal of Clinical Investigation, vol. 99, no. 5, pp. 901–914, 1997.
- C. Hartwig, M. Mazzega, H. Constabel et al., “Fcγ receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation,” European Journal of Immunology, vol. 40, no. 5, pp. 1284–1295, 2010.
- N. W. Lukacs, M. M. Glovsky, and P. A. Ward, “Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity,” American Journal of Physiology, vol. 280, no. 3, pp. L512–L518, 2001.
- B. Pulendran, H. Tang, and S. Manicassamy, “Programming dendritic cells to induce T H 2 and tolerogenic responses,” Nature Immunology, vol. 11, no. 8, pp. 647–655, 2010.
- L. S. Van Rijt, S. Jung, A. KleinJan et al., “In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma,” Journal of Experimental Medicine, vol. 201, no. 6, pp. 981–991, 2005.
- H. S. Bandukwala, B. S. Clay, J. Tong et al., “Signaling through FcγRIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1875–1889, 2007.
- T. A. E. Platts-Mills, M. D. Chapman, and D. G. Marsh, “Human immunoglobulin E and immunoglobulin G antibody responses to the “minor” ragweed allergen Ra3: correlation with skin tests and comparison with other allergens,” Journal of Allergy and Clinical Immunology, vol. 67, no. 2, pp. 129–134, 1981.
- D. Rittirsch, M. A. Flierl, D. E. Day et al., “Cross-talk between TLR4 and FcγReceptorIII (CD16) pathways,” PLoS Pathogens, vol. 5, no. 6, article e1000464, 2009.
- M. Aloulou, S. Ben Mkaddem, M. Biarnes-Pelicot et al., et al., “IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses,” Blood, vol. 119, pp. 3084–3096, 2012.
- L. M. Araujo, A. Chauvineau, R. Zhu et al., “Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms,” Journal of Immunology, vol. 186, no. 6, pp. 3289–3293, 2011.
- J. N. Samsom, L. A. Van Berkel, J. M. L. M. Van Helvoort et al., “FcγRIIB regulates nasal and oral tolerance: a role for dendritic cells,” Journal of Immunology, vol. 174, no. 9, pp. 5279–5287, 2005.
- M. Y. Viksman, M. C. Liu, C. A. Bickel, R. P. Schleimer, and B. S. Bochner, “Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 155, no. 3, pp. 858–863, 1997.
- N. E. Alexis, J. Soukup, S. Nierkens, and S. Becker, “Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma,” American Journal of Physiology, vol. 280, no. 2, pp. L369–L375, 2001.
- M. Y. Viksman, B. S. Bochner, R. S. Peebles, R. P. Schleimer, and M. C. Liu, “Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge,” Clinical Immunology, vol. 104, no. 1, pp. 77–85, 2002.
- K. Kowal, M. Moniuszko, M. Dabrowska, and A. Bodzenta-Lukaszyk, “Allergen challenge differentially affects the number of circulating monocyte subsets,” Scandinavian Journal of Immunology, vol. 75, pp. 531–539, 2012.
- S. Bajaña, N. Herrera-González, J. Narváez et al., “Differential CD4+ T-cell memory responses induced by two subsets of human monocyte-derived dendritic cells,” Immunology, vol. 122, no. 3, pp. 381–393, 2007.
- F. Jonsson, D. A. Mancardi, W. Zhao, et al., “Human FcgammaRIIA induces anaphylactic and allergic reactions,” Blood, vol. 119, pp. 2533–2544, 2012.
- P. Smith, D. J. DiLillo, S. Bournazos, F. Li, and J. V. Ravetch, “Mouse model recapitulating human Fcgamma receptor structural and functional diversity,” Proceedings of the National Academy of Sciences of USA, vol. 109, pp. 6181–6186, 2012.
- S. Lau, S. Illi, T. A. E. Platts-Mills et al., “Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood—report of the German Multicentre Allergy Study (MAS 90),” Allergy, vol. 60, no. 6, pp. 766–773, 2005.
- T. Platts-Mills, J. Vaughan, S. Squillace, J. Woodfolk, and R. Sporik, “Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study,” Lancet, vol. 357, no. 9258, pp. 752–756, 2001.
- T. A. Out, E. A. Van de Graaf, N. J. Van den Berg, and H. M. Jansen, “IgG subclasses in bronchoalveolar lavage fluid from patients with asthma,” Scandinavian Journal of Immunology, vol. 33, no. 6, pp. 719–727, 1991.
- R. Kitz, P. Ahrens, and S. Zielen, “Immunoglobulin levels in bronchoalveolar lavage fluid of children with chronic chest disease,” Pediatric Pulmonology, vol. 29, no. 6, pp. 443–451, 2000.
- V. P. Kurup, “Immunology of allergic bronchopulmonary aspergillosis,” The Indian Journal of Chest Diseases & Allied Sciences, vol. 42, no. 4, pp. 225–237, 2000.
- A. L. Lopata, M. Schinkel, P. C. Potter et al., “Qualitative and quantitative evaluation of bird-specific IgG antibodies,” International Archives of Allergy and Immunology, vol. 134, no. 2, pp. 173–178, 2004.
- B. J. Hales, A. C. Martin, L. J. Pearce et al., “IgE and IgG anti-house dust mite specificities in allergic disease,” Journal of Allergy and Clinical Immunology, vol. 118, no. 2, pp. 361–367, 2006.
- L. K. James, H. Bowen, and R. A. Calvert :, “Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy,” Journal of Allergy and Clinical Immunology, vol. 130, no. 3, pp. 663.e3–670.e3, 2012.
- V. Visco, C. Dolecek, S. Denépoux et al., “Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1,” Journal of Immunology, vol. 157, no. 2, pp. 956–962, 1996.
- J. Holm, N. Willumsen, P. A. Würtzen, L. H. Christensen, and K. Lund, “Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity,” Journal of Allergy and Clinical Immunology, vol. 127, no. 4, pp. 1029–1037, 2011.
- B. Hesselmar, B. Åberg, B. Eriksson, B. Björkstén, and N. Åberg, “High-dose exposure to cat is associated with clinical tolerance—a modified Th2 immune response?” Clinical and Experimental Allergy, vol. 33, no. 12, pp. 1681–1685, 2003.
- E. J. M. Krop, G. Doekes, D. J. J. Heederik, R. C. Aalberse, and J. S. Van Der Zee, “IgG4 antibodies against rodents in laboratory animal workers do not protect against allergic sensitization,” Allergy, vol. 66, no. 4, pp. 517–522, 2011.
- L. Portengen, G. De Meer, G. Doekes, and D. Heederik, “Immunoglobulin G4 antibodies to rat urinary allergens, sensitization and symptomatic allergy in laboratory animal workers,” Clinical and Experimental Allergy, vol. 34, no. 8, pp. 1243–1250, 2004.
- L. K. James, M. H. Shamji, S. M. Walker et al., “Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies,” Journal of Allergy and Clinical Immunology, vol. 127, no. 2, pp. 509–516, 2011.
- M. Jutel and C. A. Akdis, “Immunological mechanisms of allergen-specific immunotherapy,” Allergy, vol. 66, no. 6, pp. 725–732, 2011.
- P. Jeannin, S. Lecoanet, Y. Delneste, J. F. Gauchat, and J. Y. Bonnefoy, “IgE versus IgG4 production can be differentially regulated by IL-10,” Journal of Immunology, vol. 160, no. 7, pp. 3555–3561, 1998.
- F. Meiler, S. Klunker, M. Zimmermann, C. A. Akdis, and M. Akdis, “Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors,” Allergy, vol. 63, no. 11, pp. 1455–1463, 2008.