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Journal of Allergy
Volume 2012 (2012), Article ID 341282, 9 pages
http://dx.doi.org/10.1155/2012/341282
Review Article

Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma

1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117597
2Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228

Received 29 April 2012; Accepted 24 July 2012

Academic Editor: Yassine Amrani

Copyright © 2012 Chun Ming Teoh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Airway hyperresponsiveness (AHR) is one of the cardinal features of asthma. Contraction of airway smooth muscle (ASM) cells that line the airway wall is thought to influence aspects of AHR, resulting in excessive narrowing or occlusion of the airway. ASM contraction is primarily controlled by agonists that bind G protein-coupled receptor (GPCR), which are expressed on ASM. Integrins also play a role in regulating ASM contraction signaling. As therapies for asthma are based on symptom relief, better understanding of the crosstalk between GPCRs and integrins holds good promise for the design of more effective therapies that target the underlying cellular and molecular mechanism that governs AHR. In this paper, we will review current knowledge about integrins and GPCRs in their regulation of ASM contraction signaling and discuss the emerging concept of crosstalk between the two and the implication of this crosstalk on the development of agents that target AHR.