Table 1: Expression of different integrins in ASM, their potential ligands and change in expression in asthma.

IntegrinExpression in ASMPotential ligandsChange in expression in asthma (human)Reference

1Human, sheep, guinea pig Collagen I, II, III, IV, laminin-111, fibronectin.n.d.[2730]
2 1Human, guinea pig Collagen I, IV, laminin-111, tenascin.n.d.[2729, 31, 32]
3 1HumanCollagen I, fibronectin, laminin-211, laminin-221, laminin-322, laminin-511, laminin-521.n.d.[14, 27, 28]
4 1Human, sheepFibronectin, osteopontin, VCAM-1.[27, 28, 30, 33]
5 1Human, guinea pigFibronectin, osteopontin.[12, 27, 28, 32, 34, 35]
6 1HumanLaminin-111, laminin-411, laminin-511, laminin-521.n.d.[14, 28]
6 4HumanLaminin-322, laminin-511, laminin-521.n.d.[28]
7 1HumanLaminin-111, laminin-211, laminin-221.n.d.[14]
8 1MouseFibronectin, tenascin, vitronectinn.d.[28]
9 1Human, guinea pig, mouseADAMs 1, 2, 3, 9, 15, factor XIII, L1-Cell adhesion molecule, osteopontin, tenascin, VCAM-1, von Willebrands factor.[28, 36, 37]
v 1HumanFibronectin.[28, 32]
v 3HumanFibrinogen, fibronectin, GSP, laminin, osteopontin, thrombospondin, vitronectin, von Willebrands factor.n.d.[27, 28, 32]
v 5Human, mouseOsteopontin, vitronectin[38]

n.d.: not determined.