Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma

Table 1

Expression of different integrins in ASM, their potential ligands and change in expression in asthma.

Integrin	Expression in ASM	Potential ligands	Change in expression in asthma (human)	Reference
𝛼1𝛽1	Human, sheep, guinea pig	Collagen I, II, III, IV, laminin-111, fibronectin.	n.d.	[27–30]
𝛼2𝛽1	Human, guinea pig	Collagen I, IV, laminin-111, tenascin.	n.d.	[27–29, 31, 32]
𝛼3𝛽1	Human	Collagen I, fibronectin, laminin-211, laminin-221, laminin-322, laminin-511, laminin-521.	n.d.	[14, 27, 28]
𝛼4𝛽1	Human, sheep	Fibronectin, osteopontin, VCAM-1.	↑	[27, 28, 30, 33]
𝛼5𝛽1	Human, guinea pig	Fibronectin, osteopontin.	↑	[12, 27, 28, 32, 34, 35]
𝛼6𝛽1	Human	Laminin-111, laminin-411, laminin-511, laminin-521.	n.d.	[14, 28]
𝛼6𝛽4	Human	Laminin-322, laminin-511, laminin-521.	n.d.	[28]
𝛼7𝛽1	Human	Laminin-111, laminin-211, laminin-221.	n.d.	[14]
𝛼8𝛽1	Mouse	Fibronectin, tenascin, vitronectin	n.d.	[28]
𝛼9𝛽1	Human, guinea pig, mouse	ADAMs 1, 2, 3, 9, 15, factor XIII, L1-Cell adhesion molecule, osteopontin, tenascin, VCAM-1, von Willebrands factor.	↓	[28, 36, 37]
𝛼v𝛽1	Human	Fibronectin.	↑	[28, 32]
𝛼v𝛽3	Human	Fibrinogen, fibronectin, GSP, laminin, osteopontin, thrombospondin, vitronectin, von Willebrands factor.	n.d.	[27, 28, 32]
𝛼v𝛽5	Human, mouse	Osteopontin, vitronectin	↑	[38]

n.d.: not determined.