Therapeutic Effects and Biomarkers in Sublingual Immunotherapy: A Review

Figure 3

Proposed effects of SLIT on T cells, B cells, APC, and inflammatory cells [57]. Oral DCs or oLCs may take up allergens administered sublingually, followed by induction of Th1 or Treg cells to downregulate Th2 cells and inflammatory cells. The Treg cells also activate B cells to produce blocking antibody, which may inhibit binding between allergens and surface IgE on inflammatory cells to prevent secretion of inflammatory mediators and inhibit FAP by APCs or B cells to Th2 cells.