Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice

<table>The effect of saline (a and c) or CP-99994 (b and d) on cumulative concentration-response curves for SP and  frequency-response curves for EFS in isolated mice tracheal smooth muscle after exposure to 5 days FA (open circles) or SS-(solid circles). Values are means <svg height="9.5625" id="M47" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 10.1 9.5625" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,9.125)"><use xlink:href="#xB1"></use></g>
</svg> SE; <svg height="11.125" id="M48" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.125" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><use xlink:href="#x31"></use></g><g transform="matrix(.017,-0,0,-.017,36.168,10.862)"><path d="M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z" id="x34"></path></g>
</svg> in each group.  *Significant difference in EFS between FA and SS exposure, <svg height="11.85" id="M49" style="vertical-align:-0.546pt" version="1.1" viewbox="0 0 58.712502 11.85" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.113)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.113)"><use xlink:href="#x2264"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.113)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.113)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.113)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.113)"><use xlink:href="#x35"></use></g>
</svg>.</table>

Journal of Allergy

fig5

Figure 5

Figure 5: Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice 