- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Allergy
Volume 2012 (2012), Article ID 490905, 11 pages
Sublingual Immunotherapy Induces Regulatory Function of IL-10-Expressing CD4+CD25+Foxp3+ T Cells of Cervical Lymph Nodes in Murine Allergic Rhinitis Model
1Department of Experimental Animals, Center for Integrated Research in Science, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
2Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Received 3 April 2012; Revised 5 September 2012; Accepted 21 September 2012
Academic Editor: Robert J. Bischof
Copyright © 2012 Takaya Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. M. Naclerio, “Drug therapy: allergic rhinitis,” New England Journal of Medicine, vol. 325, no. 12, pp. 860–869, 1991.
- M. Baggiolini and C. A. Dahinden, “CC chemokines in allergic inflammation,” Immunology Today, vol. 15, no. 3, pp. 127–133, 1994.
- S. R. Durham, S. Ying, V. A. Varney et al., “Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia,” Journal of Immunology, vol. 148, no. 8, pp. 2390–2394, 1992.
- J. Freeman, “Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine,” The Lancet, vol. 178, no. 4594, pp. 814–817, 1911.
- M. Larché, C. A. Akdis, and R. Valenta, “Immunological mechanisms of allergen-specific immunotherapy,” Nature Reviews Immunology, vol. 6, no. 10, pp. 761–771, 2006.
- D. R. Wilson, M. T. Lima, and S. R. Durham, “Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis.,” Allergy, vol. 60, no. 1, pp. 4–12, 2005.
- J. B. Sun, N. Cuburu, M. Blomquist, B. L. Li, C. Czerkinsky, and J. Holmgren, “Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3+CD25+CD4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions,” Scandinavian Journal of Immunology, vol. 64, no. 3, pp. 251–259, 2006.
- M. D. Gunn, S. Kyuwa, C. Tam et al., “Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization,” Journal of Experimental Medicine, vol. 189, no. 3, pp. 451–460, 1999.
- H. Nakano and M. D. Gunn, “Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation,” Journal of Immunology, vol. 166, no. 1, pp. 361–369, 2001.
- S. Fukuyama, T. Nagatake, D. Y. Kim et al., “Cutting edge: uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis,” Journal of Immunology, vol. 177, no. 7, pp. 4276–4280, 2006.
- J. H. Song, J. I. Kim, H. J. Kwon et al., “CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination,” Journal of Immunology, vol. 182, no. 11, pp. 6851–6860, 2009.
- K. Takamura, S. Fukuyama, T. Nagatake et al., “Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis,” Journal of Immunology, vol. 179, no. 9, pp. 5897–5906, 2007.
- N. Çuburu, M. N. Kweon, J. H. Song et al., “Sublingual immunization induces broad-based systemic and mucosal immune responses in mice,” Vaccine, vol. 25, no. 51, pp. 8598–8610, 2007.
- T. Hiroi, K. Iwatani, H. Iijima, et al., “Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively,” European Journal of Immunology, vol. 28, no. 10, pp. 3346–3353, 1998.
- M. Yanagita, T. Hiroi, N. Kitagaki et al., “Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production,” Journal of Immunology, vol. 162, no. 6, pp. 3559–3565, 1999.
- L. A. Herzenberg, J. Tung, W. A. Moore, L. A. Herzenberg, and D. R. Parks, “Interpreting flow cytometry data: a guide for the perplexed,” Nature Immunology, vol. 7, no. 7, pp. 681–685, 2006.
- C. Troise, S. Voltolini, A. Canessa, S. Pecora, and A. C. Negrini, “Sublingual immunotherapy in Parietaria pollen-induced rhinitis: a double-blind study,” Journal of Investigational Allergology and Clinical Immunology, vol. 5, no. 1, pp. 25–30, 1995.
- G. Ciprandi, D. Fenoglio, I. Cirillo et al., “Sublingual immunotherapy: an update on immunologic and functional effects,” Allergy and Asthma Proceedings, vol. 28, no. 1, pp. 40–43, 2007.
- H. Moussu, L. Van Overtvelt, S. Horiot, et al., “Bifidobacterium bifidum NCC 453 promotes tolerance induction in murine models of sublingual immunotherapy,” International Archives of Allergy and Immunology, vol. 158, no. 1, pp. 35–42, 2011.
- T. Fujimura, S. Yonekura, Y. Taniguchi et al., “The induced regulatory T cell level, defined as the proportion of IL-10Foxp3+ cells among CD25+CD4+ leukocytes, is a potential therapeutic biomarker for sublingual immunotherapy: a preliminary report,” International Archives of Allergy and Immunology, vol. 153, no. 4, pp. 378–387, 2010.
- M. H. Shamji and S. R. Durham, “Mechanisms of immunotherapy to aeroallergens,” Clinical and Experimental Allergy, vol. 41, no. 9, pp. 1235–1246, 2011.
- K. I. Yamanaka, A. Yuta, M. Kakeda et al., “Induction of IL-10-producing regulatory T cells with TCR diversity by epitope-specific immunotherapy in pollinosis,” Journal of Allergy and Clinical Immunology, vol. 124, no. 4, pp. 842–845, 2009.
- P. Moingeon and L. Mascarell, “Induction of tolerance via the sublingual route: mechanisms and applications,” Clinical and Developmental Immunology, vol. 2012, Article ID 623474, 8 pages, 2012.
- L. Mascarell, N. Saint-Lu, H. Moussu, et al., “Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice,” Mucosal Immunology, vol. 4, no. 6, pp. 638–647, 2011.
- P. Moingeon, T. Batard, R. Fadel, F. Frati, J. Sieber, and L. Van Overtvelt, “Immune mechanisms of allergen-specific sublingual immunotherapy,” Allergy, vol. 61, no. 2, pp. 151–165, 2006.
- L. Mascarell, V. Lombardi, A. Zimmer et al., “Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cells,” Clinical and Experimental Allergy, vol. 39, no. 12, pp. 1910–1919, 2009.
- J. Brimnes, J. Kildsgaard, H. Jacobi, and K. Lund, “Sublingual immunotherapy reduces allergic symptoms in a mouse model of rhinitis,” Clinical and Experimental Allergy, vol. 37, no. 4, pp. 488–497, 2007.
- A. Taylor, J. Verhagen, C. A. Akdis, and M. Akdis, “T regulatory cells and allergy,” Microbes and Infection, vol. 7, no. 7-8, pp. 1049–1055, 2005.
- C. M. Hawrylowicz and A. O'Garra, “Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma,” Nature Reviews Immunology, vol. 5, no. 4, pp. 271–283, 2005.
- E. M. Shevach, “CD4+CD25+ suppressor T cells: more questions than answers,” Nature Reviews Immunology, vol. 2, no. 6, pp. 389–400, 2002.
- A. Joetham, K. Takeda, M. Okamoto et al., “Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells,” Journal of Immunology, vol. 183, no. 3, pp. 1821–1827, 2009.
- J. H. Song, H. H. Nguyen, N. Cuburu et al., “Sublingual vaccination with influenza virus protects mice against lethal viral infection,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 5, pp. 1644–1649, 2008.
- R. Förster, A. C. Davalos-Misslitz, and A. Rot, “CCR7 and its ligands: balancing immunity and tolerance,” Nature Reviews Immunology, vol. 8, no. 5, pp. 362–371, 2008.
- T. Kuwabara, F. Ishikawa, T. Yasuda et al., “CCR 7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells,” Journal of Immunology, vol. 183, no. 4, pp. 2513–2521, 2009.
- M. Kortylewski, H. Xin, M. Kujawski et al., “Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment,” Cancer Cell, vol. 15, no. 2, pp. 114–123, 2009.